Photoregulating Antifouling and Bioadhesion Functional Coating Surface Based on Spiropyran

• Published in: Chemistry : a European journal Vol. 24; no. 30; pp. 7742 - 7748
• Main Authors: Yu, Leixiao, Schlaich, Christoph, Hou, Yong, Zhang, Jianguang, Noeske, Paul‐Ludwig Michael, Haag, Rainer
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 28.05.2018
• Subjects: Adhesion; Adsorption; antifouling; Antifouling coatings; Antifouling substances; Biomolecules; Biosensors; Cell adhesion; Cell adhesion & migration; Chemistry; Coatings; controlling cell adhesion; functional coatings; Hydrophobicity; Irradiation; Molecular chains; photochemistry; Protein adsorption; Proteins; spiropyranes; Surface chemistry; Ultraviolet radiation; Zwitterions; spiropyranes; functional coatings; photochemistry; antifouling; controlling cell adhesion
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201801051

Dynamic regulation of the interactions between specific molecules on functional surfaces and biomolecules, for example, proteins or cells, is critical for biosensor and biomedical devices. Herein, we present a spiropyran (SP)‐based light‐responsive surface coating, hPG (hyperbranched polyglycerol)‐SP, to control the adsorption of proteins and adhesion of cells. In the normal state, the SP groups on the coating surface were in hydrophobic ring‐closed form, which promotes the nonspecific protein adsorption and cell adhesion. Under UV irradiation, the grafted SP groups were dynamically isomerized into hydrophilic/zwitterionic merocyanine. Both hydrophilicity and zwitterions support the formation of a hydrated layer and hence the resulting hPG‐MC coatings highly resist protein adsorption and cell adhesion. Moreover, the presented hPG also provided a robust bioinert background to suppress the nonspecific protein adsorption and cells adhesion. Therefore, this functionalized coating exhibited a good photoregulated antifouling behavior. Moreover, the detachment of adsorbed proteins and adhered cells from the coating surface was also realized. UV initiated antifouling: A spiropyran (SP)‐based light‐responsive surface coating, hPG (hyperbranched polyglycerol)‐SP, is reported to control the adsorption of proteins and adhesion of cells. In the normal state, the SP groups on the coating surface were in hydrophobic ring‐closed form, promoting protein adsorption and cell adhesion. Under UV irradiation, the grafted SP groups isomerized into hydrophilic/zwitterionic merocyanine, forming a hydrated layer leading to antifouling properties (see figure).