The Remarkable Coding Strategy of Borna Disease Virus: A New Member of the Nonsegmented Negative Strand RNA Viruses

BDV uses a remarkably broad range of mechanisms to direct expression of its 8.9-kb genome. Although much remains to be elucidated, it is clear that BDV genome expression is modulated by the use of multiple strategies, including differential gene transcription, post-transcriptional modification, and...

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Bibliographic Details
Published inVirology Vol. 210; no. 1; pp. 1 - 8
Main Authors Schneemann, Anette, Schneider, Patrick A., Lamb, Robert A., Lipkin, W.Ian
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.06.1995
Subjects
ANIMAL VIRUSES
Animals
ARN MENSAJERO
ARN MESSAGER
Base Sequence
borna disease virus
Borna disease virus - genetics
Consensus Sequence
Gene Expression
GENOMAS
GENOME
Genome, Viral
GENOMES
Humans
MESSENGER RNA
Molecular Sequence Data
Open Reading Frames
Protein Biosynthesis
PROTEINAS
PROTEINE
PROTEINS
Regulatory Sequences, Nucleic Acid
REVIEWS
RNA Processing, Post-Transcriptional
RNA Splicing
RNA Viruses - genetics
RNA, Messenger - biosynthesis
RNA, Messenger - metabolism
Terminator Regions, Genetic
TRANSCRIPTION
Transcription, Genetic
TRANSLATION
Viral Proteins - biosynthesis
Viral Proteins - genetics
VIRUS DE LOS ANIMALES
VIRUS DES ANIMAUX
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Summary:BDV uses a remarkably broad range of mechanisms to direct expression of its 8.9-kb genome. Although much remains to be elucidated, it is clear that BDV genome expression is modulated by the use of multiple strategies, including differential gene transcription, post-transcriptional modification, and translational efficiency. Further insights into the details of this multilevel system will be essential to understanding BDV biology, pathogenesis, and neurotropism.
Bibliography:L73
9558069
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ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1995.1311