On the NH Effect in Ruthenium-Catalysed Hydrogenation of Ketones: Rational Design of Phosphine-Amino-Alcohol Ligands for Asymmetric Hydrogenation of Ketones

Redesign and reduce: The graphic shows some Ru complexes of tridentate ligands that do not contain NH substituents but can catalyse ketone reduction with zero‐order dependence on ketone. In tridentate systems, a secondary amine, not a primary amine, promotes hydrogen activation. Leading on from thes...

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Bibliographic Details
Published inChemistry : a European journal Vol. 16; no. 27; pp. 8002 - 8005
Main Authors Phillips, Scott D., Fuentes, José A., Clarke, Matthew L.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 19.07.2010
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Multidisciplinary
chirality
hydrogenation
kinetics
phosphines
Physical Sciences
Science & Technology
tridentate ligands
phosphines
PRECURSOR
chirality
AROMATIC KETONES
MECHANISM
STEREOSELECTIVE HYDROGENATION
hydrogenation
HYDRIDE COMPLEXES
HIGHLY ENANTIOSELECTIVE HYDROGENATION
ORIGIN
tridentate ligands
INTERMEDIATE
kinetics
EFFICIENT
BIFUNCTIONAL CATALYSIS
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Summary:Redesign and reduce: The graphic shows some Ru complexes of tridentate ligands that do not contain NH substituents but can catalyse ketone reduction with zero‐order dependence on ketone. In tridentate systems, a secondary amine, not a primary amine, promotes hydrogen activation. Leading on from these observations, the Ru complex of a phosphine‐amino‐alcohol shown above has been found to be a good hydrogenation catalyst.
Bibliography:EPSRC
istex:7195663EFE367B3B2B169F2C419D174BC063CB4F
ArticleID:CHEM201000790
ark:/67375/WNG-NRRHRNSC-S
researchfish
UKRI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201000790