Leukemic mature B‐cell neoplasm observed during the treatment with romiplostim in patient with thrombocytopenia and liver cirrhosis

Key Clinical Message We report here a new adverse event of romiplostim which is a protein analog of thrombopoietin. Leukemic mature B‐cell neoplasm was observed during the treatment of thrombocytopenia in a patient with liver cirrhosis. Their relationship was suggested clinically but the mechanism o...

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Bibliographic Details
Published inClinical case reports Vol. 6; no. 6; pp. 1087 - 1089
Main Authors Osawa, Marina, Akiyama, Hideki, Mae, Sunao, Fujiwara, Yuko, Yamane, Michio
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.06.2018
John Wiley and Sons Inc
Subjects
Case Report
Case Reports
Cirrhosis
Liver cirrhosis
mature B‐cell neoplasm
romiplostim
Tumors
Cirrhosis
mature B‐cell neoplasm
romiplostim
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Summary:Key Clinical Message We report here a new adverse event of romiplostim which is a protein analog of thrombopoietin. Leukemic mature B‐cell neoplasm was observed during the treatment of thrombocytopenia in a patient with liver cirrhosis. Their relationship was suggested clinically but the mechanism of leukemic expansion of lymphoma cells was not clarified. We report here a new adverse event of romiplostim which is a protein analog of thrombopoietin. Leukemic mature B‐cell neoplasm was observed during the treatment of thrombocytopenia in a patient with liver cirrhosis. Their relationship was suggested clinically but the mechanism of leukemic expansion of lymphoma cells was not clarified.
Bibliography:Attension: The term “Nitobe Memorial Nakano General Hospital” is the official name of “Nitobe Kinen Nakano Sogo Byoin.”
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.1530