Gender Differences in Analgesia for Endodontic Pain

Abstract The purpose of this prospective clinical trial was to investigate the analgesic efficacy of three oral medication groups on postoperative endodontic pain in male and female dental patients, with an emphasis on analgesic differences between the sexes. Forty-three patients were administered i...

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Bibliographic Details
Published inJournal of endodontics Vol. 34; no. 5; pp. 552 - 556
Main Authors Ryan, Jeffrey L., DDS, MS, Jureidini, Badri, DDS, MS, Hodges, James S., PhD, Baisden, Michael, DDS, Swift, James Q., DDS, Bowles, Walter R., DDS, MS
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2008
Subjects
Analgesia
Analgesics, Non-Narcotic - therapeutic use
Analgesics, Opioid - therapeutic use
Dentistry
Double-Blind Method
Drug Combinations
Endocrinology & Metabolism
Female
Humans
Ibuprofen - therapeutic use
Likelihood Functions
Linear Models
Male
Naloxone - therapeutic use
Pain Measurement
Pain, Postoperative - drug therapy
Pain, Postoperative - etiology
pentazocine
Pentazocine - therapeutic use
Periapical Periodontitis - surgery
Prospective Studies
Pulpitis - surgery
Root Canal Therapy - adverse effects
sex
Sex Factors
Surveys and Questionnaires
Toothache - drug therapy
Analgesia
pentazocine
sex
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Summary:Abstract The purpose of this prospective clinical trial was to investigate the analgesic efficacy of three oral medication groups on postoperative endodontic pain in male and female dental patients, with an emphasis on analgesic differences between the sexes. Forty-three patients were administered ibuprofen 600 mg, placebo, or pentazocine 50 mg/0.5 mg naloxone in a randomized, double-blinded manner. Beginning immediately after endodontic treatment, patients took the assigned medication every 6 hours for 24 hours and recorded their degree of discomfort on a 100-mm visual analog scale. Statistical analysis of the data showed that ibuprofen 600 mg provided statistically significantly greater analgesia than placebo at 6 and 12 hours ( P = 0.0014 and 0.0024), and pentazocine/naloxone provided statistically significantly greater analgesia than placebo at 12 hours ( P = 0.0084). Sex-dependent differences were noted within the pentazocine/naloxone group, which showed significantly greater analgesia in females compared with males ( P = 0.007).
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ISSN:0099-2399
1878-3554
DOI:10.1016/j.joen.2008.01.021