Ocular vaccinia following exposure to a smallpox vaccinee

• Published in: American journal of ophthalmology Vol. 137; no. 3; pp. 554 - 556
• Main Authors: Hu, Gang, Wang, Marcus J., Miller, Marjorie J., Holland, Gary N., Bruckner, David A., Civen, Rachel, Bornstein, Lee A., Mascola, Laurene, Lovett, Michael A., Mondino, Bartly J., Pegues, David A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2004; Elsevier; Elsevier Limited
• Subjects: Adult; Antiviral Agents - therapeutic use; Biological & chemical terrorism; Biological and medical sciences; Blepharitis - diagnosis; Blepharitis - drug therapy; Blepharitis - etiology; Conjunctiva - virology; Conjunctivitis, Viral - diagnosis; Conjunctivitis, Viral - drug therapy; Conjunctivitis, Viral - etiology; Disease Transmission, Infectious; Female; Fluorescent Antibody Technique, Indirect; Human viral diseases; Humans; Immunization; Immunoglobulins, Intravenous - therapeutic use; Infectious diseases; Medical sciences; Military Personnel; Polymerase Chain Reaction; Smallpox; Smallpox Vaccine - adverse effects; Trifluridine - therapeutic use; Vaccination - adverse effects; Vaccines; Vaccinia - transmission; Vaccinia virus - isolation & purification; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; United States > US; Infection; Case study; Human; Eye; Smallpox; Eye disease; Skin disease; Ocular; Viral disease; Female; Exposure; Vaccinia
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2003.09.013

To describe the presentation and management of the first identified case of ocular vaccinia infection associated with the current smallpox vaccination program. Case report. Vaccinia virus was isolated by cell culture of a conjunctival swab. Direct staining with fluorescein isothiocyanate-labeled vaccinia antibody and polymerase chain reaction testing confirmed the diagnosis. In February 2003, a 26-year-old woman developed right preseptal cellulitis and blepharoconjunctivitis following contact with a vaccinated member of the military. The preseptal cellulitis resolved with antibacterial therapy, and the conjunctival infection was treated successfully with a 14-day course of topical trifluridine and a single dose of intravenous vaccinia immune globulin. To facilitate rapid diagnosis and appropriate treatment, clinicians must maintain a high index of suspicion for ocular smallpox vaccine-associated adverse reactions in vaccine recipients and their close contacts.