Evaluation of an inactivated rabies virus vaccine in domestic ferrets

Efficacy of an SC-administered commercial inactivated vaccine for prevention of rabies was evaluated in domestic ferrets. Ferret immunity was challenged by the IM inoculation of street rabies virus. All ferrets developed titers of rabies virus-neutralizing antibodies within 30 days of vaccination (g...

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Published inJournal of the American Veterinary Medical Association Vol. 196; no. 10; pp. 1614 - 1616
Main Authors Rupprecht, C.E, Gilbert, J, Pitts, R, Marshall, K.R, Koprowski, H
Format Journal Article
LanguageEnglish
Published United States 15.05.1990
Subjects
Animals
Antibodies, Viral - biosynthesis
antibody titer
Carnivora
disease prevention
Evaluation Studies as Topic
Female
Ferrets
live vaccines
Male
Neutralization Tests
rabies
Rabies - prevention & control
Rabies - veterinary
Rabies Vaccines - immunology
Rabies virus - immunology
Random Allocation
Vaccines, Inactivated - immunology
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Summary:Efficacy of an SC-administered commercial inactivated vaccine for prevention of rabies was evaluated in domestic ferrets. Ferret immunity was challenged by the IM inoculation of street rabies virus. All ferrets developed titers of rabies virus-neutralizing antibodies within 30 days of vaccination (geometric mean titer [GMT] = 154, n = 41) that were maintained for at least one year (GMT = 106, n = 36), compared with no seroconversion in controls (GMT less than 5, n = 39). Following rabies virus challenge inoculation, 89% (32/36) of vaccinated ferrets survived vs less than 6% (2/38) survival in control ferrets. These results demonstrate the protective efficacy of a commercial, inactivated rabies vaccine of at least one year's duration for domestic ferrets.
ISSN:0003-1488
1943-569X
DOI:10.2460/javma.1990.196.10.1614