Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus

• Published in: Journal of international medical research Vol. 42; no. 2; pp. 581 - 588
• Main Authors: Sefil, Fatih, Ulutas, Kemal Turker, Dokuyucu, Recep, Sumbul, Ahmet Taner, Yengil, Erhan, Yagiz, Abdullah Erman, Yula, Erkan, Ustun, Ihsan, Gokce, Cumali
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2014; Sage Publications
• Subjects: Biological and medical sciences; Blood Glucose - physiology; Diabetes Mellitus, Type 2 - immunology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glycated Hemoglobin A - metabolism; Humans; Leukocytosis - immunology; Lymphocyte Count; Lymphocytes - cytology; Lymphocytes - immunology; Male; Medical sciences; Middle Aged; Neutrophils - cytology; Neutrophils - immunology; Retrospective Studies; neutrophil lymphocyte ratio; Glycosylated haemoglobin (HbA1c); diabetes mellitus; Endocrinopathy; Type 2 diabetes; Human; Biological fluid; Glycosylated haemoglobin (HbA; Metabolic diseases; ); Glucose; Blood; Hemoglobin A1c; Glycated hemoglobin; Neutrophil; Lymphocyte
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060513516944

Objective Leukocytosis is thought to be directly associated with the pathogenesis of atherosclerosis and metabolic syndrome. Increased white blood cell (WBC) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (NLR) is associated with metabolic syndrome. There is little information, however, concerning a correlation between glycosylated haemoglobin (HbA1c) and NLR. The aim of the present study was to investigate the relationship between NLR and blood glucose regulation. Methods This retrospective study was conducted in patients with type 2 diabetes mellitus, divided into two groups according to HbA1c levels: group 1, HbA1c levels ≤ 7%; group 2, HbA1c levels > 7%. Venous WBC, neutrophil and lymphocyte counts were determined. Results Of 71 patients included, fasting serum glucose, neutrophil and WBC counts were significantly higher in group 2 compared with group 1. NLR had a positive correlation with HbA1c. Conclusion There may be a significant relationship between NLR and blood glucose regulation. The authors propose that increased NLR may be associated with elevated HbA1c in patients with type 2 diabetes mellitus.