The effect of hyperbaric oxygen on neuroregeneration following acute thoracic spinal cord injury

• Published in: Life sciences (1973) Vol. 90; no. 9-10; pp. 360 - 364
• Main Authors: Dayan, Kamil, Keser, Aysegul, Konyalioglu, Sibel, Erturk, Mete, Aydin, Figen, Sengul, Gulgun, Dagci, Taner
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 27.02.2012
• Subjects: Acute Disease; Aneurysm; Animals; Blood-brain barrier; Catalase; Catalase - analysis; Disease Models, Animal; Enzymes; Glutathione peroxidase; Glutathione Peroxidase - analysis; histology; Hyperbaric oxygen; Hyperbaric Oxygenation; Male; Motor Activity - drug effects; Nitric oxide; Nitric Oxide - analysis; Nitric oxide rat; Nitric Oxide Synthase - analysis; Nitric-oxide synthase; oxygen; Oxygen - therapeutic use; Rats; Rats, Sprague-Dawley; Recovery of function; Recovery of Function - drug effects; spinal cord; Spinal Cord - enzymology; Spinal Cord - physiology; Spinal Cord Injuries - enzymology; Spinal Cord Injuries - therapy; Spinal cord injury; Spinal Cord Regeneration; Spine; Superoxide dismutase; Superoxide Dismutase - analysis; Thorax; Vertebrae; Superoxide dismutase; Nitric oxide rat; Catalase; Spinal cord injury
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2011.12.005

Although hyperbaric oxygen (HBO) treatment following spinal cord injury (SCI) have been studied in terms of neurological function and tissue histology, there is a limited number studies on spinal cord tissue enzyme levels. The effect of HBO treatment in SCI was investigated by measuring superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), nitric oxide synthase (NOS) and nitric oxide (NO) activity in the injured tissue. SCI was induced by applying an aneurysm clip extradurally at the level of T9-T11 vertebrae. Preoperative HBO (preopHBO) treatment was applied for 5days and postoperative HBO (postopHBO) for 7days. In the preopHBO group, a significant decrease was observed in NOS and NO compared to the SCI group. There was a decrease in SOD, NOS and NO in the postopHBO group when compared to the SCI group. In the pre–postHBO group SOD, GPx, NOS and NO decreased significantly. There was a decrease in SOD in postopHBO compared to preopHBO. In the prepostopHBO, SOD decreased significantly compared to that in the preopHBO group. The prepostopHBO presented a significant decrease in GPx compared to postopHBO (p<0.05 for all parameters). No significant difference was observed for catalase for all groups. Significant improvement was found in BBB scores for both postopHBO and prepostHBO groups when compared to the SCI group (p<0.05). HBO treatment was found to be beneficial following SCI in terms of biochemical parameters and functional recovery in the postoperative period.