Continuous Lines of Basophil/Mast Cells Derived from Normal Mouse Bone Marrow

Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophil/mast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and thei...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 212; no. 4492; pp. 333 - 335
Main Authors Nagao, Kenji, Yokoro, Kenjiro, Aaronson, Stuart A.
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 17.04.1981
Subjects
Adipocytes
Animals
Antigens
Basophils
Bone marrow
Bone Marrow Cells
Cell Differentiation
Cell Line
Cell lines
Culture Techniques
Cultured cells
Hematopoietic Stem Cells
Histocytochemistry
Mast Cells
Mice
Mice, Inbred Strains
Myeloid cells
Stem cells
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Summary:Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophil/mast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and their lack of tumorigenicity despite long-term culture makes these cell lines potentially important for studies of the mechanisms of allergic reactions and inflammation as well as the differentiation pathways involving this subset of hematopoietic cells.
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content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7209531