Haemodynamic Adaptive Mechanisms at High Altitude: Comparison between European Lowlanders and Nepalese Highlanders

• Published in: Journal of clinical medicine Vol. 11; no. 13; p. 3843
• Main Authors: Salvi, Paolo, Grillo, Andrea, Gautier, Sylvie, Montaguti, Luca, Brunacci, Fausto, Severi, Francesca, Salvi, Lucia, Pretolani, Enzo, Parati, Gianfranco, Benetos, Athanase
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.07.2022; MDPI
• Subjects: Airports; Altitude; Blood pressure; Clinical medicine; Edema; Hemodynamics; Hypoxia; Laboratories; Oxygen saturation; Sea level; Statistical analysis; Veins & arteries; Viscoelasticity; United States > US; Italy; altitude; blood pressure; aortic distensibility; aortic stiffness; altitude sickness; atrial natriuretic factor; vascular stiffness; pulse wave velocity
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm11133843

Background: Exposure to high altitudes determines several adaptive mechanisms affecting in a complex way the whole cardiovascular, respiratory, endocrine systems because of the hypobaric hypoxic condition. The aim of our study was to evaluate the circulatory adaptive mechanisms at high altitudes, during a scientific expedition in the Himalayas. Methods: Arterial distensibility was assessed measuring carotid-radial and carotid-femoral pulse wave velocity. Tests were carried out at several altitudes, from 1350 to 5050 m above sea level, on 8 lowlander European researchers and 11 highlander Nepalese porters. Results: In Europeans, systolic blood pressure and pulse pressure increased slightly but significantly with altitude (p < 0.05 and p < 0.001, respectively). Norepinephrine showed a significant increase after the lowlanders had spent some time at high altitude (p < 0.001). With increasing altitude, a progressive increase in carotid-radial and carotid-femoral pulse wave velocity values was observed in lowlanders, showing a particularly significant increase (p < 0.001) after staying at high altitude (carotid-radial pulse wave velocity, median value (interquartile range) from 9.2 (7.9−10.0) to 11.2 (10.9−11.8) m/s and carotid-femoral pulse wave velocity from 8.5 (7.9−9.0) to 11.3 (10.9−11.8) m/s). At high altitudes (3400 and 5050 m above sea level), no significant differences were observed between highlanders and lowlanders in hemodynamic parameters (blood pressure, carotid-radial and carotid-femoral pulse wave velocity). Conclusions: The progressive arterial stiffening with altitude observed in European lowlanders could explain the increase in systolic and pulse pressure values observed at high altitudes in this ethnic group. Further studies are needed to evaluate the role of aortic stiffening in the pathogenesis of acute mountain sickness.