A potential role of EMMPRIN by regulating ECM degradation in periodontitis

Summary Periodontitis are characterized by the destruction of the extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) play an important role in the degradation of ECM. But until now, it is not clear about the regulation of MMPs expression level in periodontitis. EMMPR...

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Bibliographic Details
Published inMedical hypotheses Vol. 69; no. 5; pp. 1102 - 1104
Main Authors Cao, ZhengGuo, Xiang, JunBo, Li, ChengZhang
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 2007
Subjects
Animals
Basigin - immunology
Extracellular Matrix - immunology
Extracellular Matrix - pathology
Homeostasis - immunology
Humans
Internal Medicine
Models, Immunological
Periodontitis - immunology
Periodontitis - pathology
Signal Transduction - immunology
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Summary:Summary Periodontitis are characterized by the destruction of the extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) play an important role in the degradation of ECM. But until now, it is not clear about the regulation of MMPs expression level in periodontitis. EMMPRIN is a 58 kDa, highly glycosylated, transmembrane molecule belonging to the immunoglobin superfamily, which interacts with fibroblasts to stimulate the expression of MMPs. It is logical to postulate that EMMPRIN may play a critical role in the regulation of MMPs participating the destruction of periodontal ECM in periodontitis. The hypothesis will provide the brand-new direction that we may prevent and treat the periodontitis by regulating the expression of EMMPRIN in host aspect.
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ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2007.01.086