Translocation (1;10)(p34;p15) in infant acute myeloid leukemia with extramedullary infiltration in multiple sites

• Published in: Cancer genetics and cytogenetics Vol. 192; no. 2; pp. 86 - 89
• Main Authors: Funato, Michinori, Fukao, Toshiyuki, Sasai, Hideo, Hori, Tomohiro, Terazawa, Daisuke, Ozeki, Michio, Orii, Kenji, Teramoto, Takahide, Kaneko, Hideo, Kondo, Naomi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.07.2009
• Subjects: Bone Marrow - pathology; Chromosomes, Human, Pair 1 - genetics; Chromosomes, Human, Pair 10 - genetics; Hematology, Oncology and Palliative Medicine; Humans; In Situ Hybridization, Fluorescence; Infant; Karyotyping; Leukemia, Myeloid, Acute - complications; Leukemia, Myeloid, Acute - diagnostic imaging; Leukemia, Myeloid, Acute - genetics; Leukemic Infiltration - complications; Leukemic Infiltration - diagnostic imaging; Leukemic Infiltration - genetics; Medical Education; Tomography, X-Ray Computed; Translocation, Genetic
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/j.cancergencyto.2009.04.010

Abstract Primary acute myeloid leukemia (AML) with extramedullary infiltration (EMI) in multiple sites is rare. Herein, we describe a case of infant AML with EMI in multiple sites. She had dyspnea and hypofibrinogenemia at diagnosis, and systemic computed tomography revealed EMI in the orbit, gingiva, bronchial pathway, and urinary tract. Bone marrow examination confirmed the diagnosis of AML with t(1;10)(p34;p15). No case of AML with t(1;10)(p34;p15) has been reported in the literature. At the present time, she remains free of disease 12 months after bone marrow transplantation (BMT) in the second complete remission.