Controlled assembly of multi-segment nanowires by histidine-tagged peptides

A facile technique was demonstrated for the controlled assembly and alignment of multi-segment nanowires using bioengineered polypeptides. An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advan...

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Published inNanotechnology Vol. 17; no. 14; pp. 3375 - 3379
Main Authors Wang, Aijun A, Lee, Joun, Jenikova, Gabriela, Mulchandani, Ashok, Myung, Nosang V, Chen, Wilfred
Format Journal Article
LanguageEnglish
Published England IOP Publishing 28.07.2006
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Summary:A facile technique was demonstrated for the controlled assembly and alignment of multi-segment nanowires using bioengineered polypeptides. An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. The affinity between the His(6) domain of biopolymers and the nickel segment of multi-segment nickel/gold/nickel nanowires was exploited for the directed assembly of nanowires onto peptide-functionalized electrode surfaces. The presence of the ferromagnetic nickel segments on the nanowires allowed the control of directionality by an external magnetic field. Using this method, the directed assembly and positioning of multi-segment nanowires across two microfabricated nickel electrodes in a controlled manner was accomplished with the expected ohmic contact.
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ISSN:0957-4484
1361-6528
1361-6528
DOI:10.1088/0957-4484/17/14/006