Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: A review

• Published in: International journal of pharmaceutics Vol. 580; p. 119200
• Main Authors: Jennotte, Olivier, Koch, Nathan, Lechanteur, Anna, Evrard, Brigitte
• Format: Journal Article Web Resource
• Language: English
• Published: Netherlands Elsevier B.V 30.04.2020; Elsevier
• Subjects: Aqueous solubility enhancement; aqueous soluiblity enhancement; Biological Availability; Chemistry, Pharmaceutical - instrumentation; Chemistry, Pharmaceutical - methods; Drug delivery systems; drug delivrey systems; Human health sciences; Pharmaceutical Preparations - chemical synthesis; Pharmaceutical Preparations - metabolism; Pharmaceutics; Pharmacie, pharmacologie & toxicologie; Pharmacy, pharmacology & toxicology; Printing, Three-Dimensional; Sciences de la santé humaine; Solubility; Technology, Pharmaceutical - instrumentation; Technology, Pharmaceutical - methods; Three-dimensional printing; Water - chemistry; Water - metabolism; HME; Drug delivery systems; FDA; Pharmaceutics; HPβCD; PEGDA; Three-dimensional printing; SLA; PVP; FDM; ASD; BCS; PEG; PLGA; TEC; DSC; PEGDMA; Aqueous solubility enhancement; API; PVA; PEO; SLS; HPMC
• ISSN: 0378-5173; 1873-3476; 1873-3476
• DOI: 10.1016/j.ijpharm.2020.119200

[Display omitted] Poor aqueous solubility of active pharmaceutical ingredients (API) is nowadays a major issue in the pharmaceutical field. The combinatorial chemistry provides more and more API with a great therapeutic potential, but with a low aqueous solubility. Among the strategies to overcome this drawback, the use of amorphous solid dispersions (ASD), as well as the increase of surface area, is widely used. The three dimensional (3D) printing technologies appear to be innovative tools allowing the construction of any unconventional forms with different composition, structure or infill; especially by using ASD materials. This review aims to deliver notions about the different 3D printing techniques found in the literature to improve aqueous solubility of several API, namely nozzle-based method, inkjet methods and laser- based methods, as well as guide formulator in terms of formulation parameters that have to be optimized to allow the most suitable impression of innovative medicines.