What causes lymphocyte hyporesponsiveness during filarial nematode infection?

Filarial nematodes persist in the parasitized host by modulating immune responsiveness. A feature of this that has been observed in a multitude of studies dating back several decades is an inability of lymphocytes to respond appropriately to filarial nematode antigens and, in some cases, to other st...

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Published inTrends in parasitology Vol. 22; no. 3; pp. 105 - 110
Main Authors Harnett, William, Harnett, Margaret M.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.03.2006
Elsevier
Subjects
Animals
Biological and medical sciences
Experimental protozoal diseases and models
Filariasis - immunology
Filariasis - parasitology
Humans
Immune Tolerance
Infectious diseases
Lymphocyte Activation
Lymphocytes - immunology
Medical sciences
Nematoda
Parasitic diseases
Protozoal diseases
Infection
Parasite
Parasitosis
Helminthiasis
Lymphocyte
Nematode disease
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Summary:Filarial nematodes persist in the parasitized host by modulating immune responsiveness. A feature of this that has been observed in a multitude of studies dating back several decades is an inability of lymphocytes to respond appropriately to filarial nematode antigens and, in some cases, to other stimuli. The consistency of this observation, allied to the ease of measurement of lymphocyte hyporesponsiveness, has resulted in many attempts to understand its cause.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2006.01.010