Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase

Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and eukarya, and, in the mid-1990s, in archaea. Th...

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Bibliographic Details
Published inJournal of bacteriology Vol. 202; no. 6
Main Authors Kelman, Lori M., O’Dell, William B., Kelman, Zvi
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 25.02.2020
Subjects
Archaea
Bacteriology
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA helicase
Maintenance
Minireview
Phages
Replication
Unwinding
United States > US
minichromosome maintenance
DNA replication
helicase
MCM
three-dimensional structure
archaea
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Summary:Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and eukarya, and, in the mid-1990s, in archaea. This year marks the 20th anniversary of the first report on the archaeal replicative helicase, the minichromosome maintenance (MCM) protein. Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and eukarya, and, in the mid-1990s, in archaea. This year marks the 20th anniversary of the first report on the archaeal replicative helicase, the minichromosome maintenance (MCM) protein. This minireview summarizes 2 decades of work on the archaeal MCM.
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Citation Kelman LM, O’Dell WB, Kelman Z. 2020. Unwinding 20 years of the archaeal minichromosome maintenance helicase. J Bacteriol 202:e00729-19. https://doi.org/10.1128/JB.00729-19.
ISSN:0021-9193
1098-5530
1098-5530
DOI:10.1128/JB.00729-19