Cancer as a robust system: implications for anticancer therapy

Cancers are extremely complex, heterogeneous diseases. Many approaches to anticancer treatment have had limited success -- cures are still rare. A fundamental hurdle to cancer therapy is acquired tumour 'robustness'. The goal of this article is to present a perspective on cancer as a robus...

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Bibliographic Details
Published inNature reviews. Cancer Vol. 4; no. 3; pp. 227 - 235
Main Author Kitano, Hiroaki
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.03.2004
Subjects
Antineoplastic Agents - therapeutic use
Cancer
Care and treatment
Diagnosis
Drug Design
Humans
Models, Biological
Neoplasms - drug therapy
Neoplasms - pathology
Japan
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Summary:Cancers are extremely complex, heterogeneous diseases. Many approaches to anticancer treatment have had limited success -- cures are still rare. A fundamental hurdle to cancer therapy is acquired tumour 'robustness'. The goal of this article is to present a perspective on cancer as a robust system to provide a framework from which the complexity of tumours can be approached to yield novel therapies.
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ISSN:1474-175X
1474-1768
DOI:10.1038/nrc1300