New alkaloids from Aconitum taipaicum and their cytotoxic activities

• Published in: Natural product research Vol. 28; no. 3; pp. 164 - 168
• Main Authors: Guo, Zeng-Jun, Xu, Ying, Zhang, Hui, Li, Meng-Yi, Xi, Ke
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.02.2014
• Subjects: Aconitine - analogs & derivatives; Aconitine - chemistry; Aconitine - isolation & purification; Aconitine - pharmacology; aconitine-type C; Aconitum - chemistry; Aconitum taipaicum; Algorithms; Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; cytotoxic activities; diterpenoid alkaloids; Doxorubicin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; K562 Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots - chemistry; Stereoisomerism
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2013.861832

Three new aconitine-type C 19 -diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (2) and (1α,6α,8α,14α,16α)-20-ethyl-1,8,14-trihydroxy-6,16-dimethoxy-4-(methoxymethyl)-aconitane (3), respectively, on the basis of spectroscopic analyses, mainly MS, 1D and 2D NMR. The cytotoxic activities of these compounds were also assayed, and the results were quite impressive.