Challenges in the Diagnosis and Management of Fibrotic Hypersensitivity Pneumonitis: A Practical Review of Current Approaches

• Published in: Journal of clinical medicine Vol. 11; no. 6; p. 1473
• Main Authors: Moua, Teng, Petnak, Tananchai, Charokopos, Antonios, Baqir, Misbah, Ryu, Jay H
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.03.2022; MDPI
• Subjects: Antibodies; Antigens; Asymptomatic; Birds; Clinical medicine; Confidence; Disease; Laboratories; Lavage; Mold; Patients; Review; hypersensitivity pneumonitis; interstitial lung disease; lung fibrosis
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm11061473

Recent advances in fibrotic hypersensitivity pneumonitis include improved diagnostic guidance, systematic assessments of immunosuppressive therapy, and the recent availability of antifibrotic therapy (nintedanib) for those with progressive disease. A standardized approach to diagnosis may lead to better inclusion criteria for future therapeutic protocols and delineation of disease or treatment response predictors for real-world management. This review will highlight current diagnostic and treatment challenges and remaining knowledge gaps or areas of uncertainty, with a practical overview of supporting evidence and its clinical implications. Exposure history, serologic testing for antigen sensitivity, bronchoalveolar lavage lymphocytosis, histopathology, and radiologic findings will be covered in the diagnosis section, with immunosuppression, antifibrotic therapy, lung transplantation, and disease prognosis in the treatment and management section.