Three single nucleotide polymorphisms of the vascular endothelial growth factor (VEGF) gene and glioma risk in a Chinese population

• Published in: Journal of international medical research Vol. 41; no. 5; pp. 1484 - 1494
• Main Authors: Jiang, Haitao, Lian, Minxue, Xie, Jiangtao, Li, Jinzheng, Wang, Maode
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2013; Sage Publications
• Subjects: Adult; Alleles; Asian Continental Ancestry Group; Biological and medical sciences; Case-Control Studies; Central Nervous System Neoplasms - diagnosis; Central Nervous System Neoplasms - ethnology; Central Nervous System Neoplasms - genetics; Central Nervous System Neoplasms - pathology; Female; Gene Frequency; Genotype; Glioma - diagnosis; Glioma - ethnology; Glioma - genetics; Glioma - pathology; Humans; Male; Medical sciences; Middle Aged; Neoplasm Grading; Neurology; Pharmacology. Drug treatments; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prognosis; Promoter Regions, Genetic; Risk; Tumors of the nervous system. Phacomatoses; Vascular Endothelial Growth Factor A - genetics; Asia; China; gene polymorphism; Glioma; vascular endothelial growth factor; VEGF; Nervous system diseases; Vascular endothelium growth factor; Gene; Central nervous system disease; Risk factor; Genetics; Tumor; Single nucleotide polymorphism
• ISSN: 0300-0605; 1473-2300; 1473-2300
• DOI: 10.1177/0300060513498667

Objective To investigate the association between three single nucleotide polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) gene and the risk of glioma in a Han Chinese population. Methods This hospital-based case–control study used polymerase chain reaction–restriction fragment length polymorphism analysis to detect three SNPs (−634 G/C, +936 C/T and +1612 G/A) of the VEGF gene in patients with glioma compared with healthy control subjects. Results The study investigated 880 patients with gliomas and 880 age- and sex-matched healthy control subjects. Patients with gliomas had a significantly higher frequency of the −634 CC genotype (odds ratio [OR] 1.35, 95% confidence interval [CI] 1.05, 1.75) and the +936 TT (OR 1.73, 95% CI 1.20, 2.48) genotype compared with the control subjects. Patients with glioblastomas had a significantly higher frequency of the −634 CC and +936 TT genotypes. Patients with grade IV gliomas had a significantly higher frequency of the −634 CC and +936 TT genotypes. The +1612 G/A polymorphisms were not associated with glioma risk. Conclusion The VEGF − 634 CC and +936 TT genotypes were associated with a higher risk of glioma in a Han Chinese population.