HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4 + T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral gluten challenge. Combining intracellular cytoki...
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Published in | Mucosal immunology Vol. 3; no. 6; pp. 594 - 601 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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01.11.2010
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Abstract | We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4
+
T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral gluten challenge. Combining intracellular cytokine staining with DQ2-α-II gliadin peptide tetramer staining of intestinal polyclonal T-cell lines, we found that gluten-specific T cells produced interferon-γ (IFN-γ) and IL-21, but not IL-17 or IL-22, even if other T cells of the same lines produced these cytokines. Similarly, in DQ2-α-II-specific T cells in peripheral blood of gluten-challenged patients, very few stained for intracellular IL-17, whereas many cells stained for IFN-γ. We conclude that gluten-reactive T cells produce IL-21 and IFN-γ, but not IL-17. Their production of IL-21 suggests a role for this cytokine in the pathogenesis of celiac disease. |
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AbstractList | We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4+ T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral gluten challenge. Combining intracellular cytokine staining with DQ2-α-II gliadin peptide tetramer staining of intestinal polyclonal T-cell lines, we found that gluten-specific T cells produced interferon-γ (IFN-γ) and IL-21, but not IL-17 or IL-22, even if other T cells of the same lines produced these cytokines. Similarly, in DQ2-α-II-specific T cells in peripheral blood of gluten-challenged patients, very few stained for intracellular IL-17, whereas many cells stained for IFN-γ. We conclude that gluten-reactive T cells produce IL-21 and IFN-γ, but not IL-17. Their production of IL-21 suggests a role for this cytokine in the pathogenesis of celiac disease. We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4 + T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral gluten challenge. Combining intracellular cytokine staining with DQ2-α-II gliadin peptide tetramer staining of intestinal polyclonal T-cell lines, we found that gluten-specific T cells produced interferon-γ (IFN-γ) and IL-21, but not IL-17 or IL-22, even if other T cells of the same lines produced these cytokines. Similarly, in DQ2-α-II-specific T cells in peripheral blood of gluten-challenged patients, very few stained for intracellular IL-17, whereas many cells stained for IFN-γ. We conclude that gluten-reactive T cells produce IL-21 and IFN-γ, but not IL-17. Their production of IL-21 suggests a role for this cytokine in the pathogenesis of celiac disease. |
Author | Tollefsen, S Sollid, L M Lundin, K E A Bodd, M Ráki, M Bergseng, E Fallang, L E |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20571486$$D View this record in MEDLINE/PubMed |
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Snippet | We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4
+
T cells of celiac disease patients,... We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4(+) T cells of celiac disease patients,... We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4+ T cells of celiac disease patients,... |
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SubjectTerms | 631/250/1619/554/1898 631/45/127 692/699/1503/1581/1357 Allergology Antibodies Biomedical and Life Sciences Biomedicine CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology Celiac Disease - immunology Cell Line Gastroenterology Gliadin - immunology Gliadin - metabolism Glutens - immunology HLA-DQ Antigens - immunology HLA-DQ Antigens - metabolism Humans Immunology Interleukin-17 - metabolism Interleukin-22 Interleukins - metabolism Intestines - immunology Intestines - pathology Peptide Fragments - immunology Peptide Fragments - metabolism |
Title | HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22 |
URI | http://dx.doi.org/10.1038/mi.2010.36 https://link.springer.com/article/10.1038/mi.2010.36 https://www.ncbi.nlm.nih.gov/pubmed/20571486 https://www.proquest.com/docview/1782999839 https://search.proquest.com/docview/759326017 |
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