Neuropeptides Regulate Expression of Angiogenic Growth Factors in Human Dental Pulp Fibroblasts

Abstract Introduction Neuropeptides play an important role in inflammation and repair and have been implicated in mediating angiogenesis. Pulp fibroblasts express neuropeptide receptors, and the aim of this research was to investigate whether neuropeptides could regulate angiogenic growth factor exp...

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Published inJournal of endodontics Vol. 35; no. 6; pp. 829 - 833
Main Authors El karim, Ikhlas A., BDS, PhD, Linden, Gerard J., BDS, BSc, PhD, Irwin, Chris R., BSc, BDS, PhD, Lundy, Fionnuala T., BSc, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2009
Subjects
Angiogenesis
Angiogenesis Modulating Agents - pharmacology
Angiogenic Proteins - biosynthesis
Cells, Cultured
dental pulp
Dental Pulp - blood supply
Dental Pulp - cytology
Dental Pulp - drug effects
Dental Pulp - metabolism
Dentistry
Endocrinology & Metabolism
Fibroblasts - drug effects
Fibroblasts - metabolism
growth factors
Growth Substances - biosynthesis
Humans
Neovascularization, Physiologic - drug effects
neuropeptides
Neuropeptides - pharmacology
Neuropeptides - physiology
Up-Regulation
Angiogenesis
dental pulp
neuropeptides
growth factors
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Summary:Abstract Introduction Neuropeptides play an important role in inflammation and repair and have been implicated in mediating angiogenesis. Pulp fibroblasts express neuropeptide receptors, and the aim of this research was to investigate whether neuropeptides could regulate angiogenic growth factor expression in vitro Methods An angiogenic array was used to determine the levels of 10 angiogenic growth factors expressed by human pulp fibroblasts. Results Pulp fibroblasts were shown to express angiogenin, angiopoietin-2, epidermal growth factor, basic fibroblast growth factor, heparin-binding epidermal growth factor, hepatocyte growth factor, leptin, platelet-derived growth factor, placental growth factor, and vascular endothelial growth factor. Furthermore, the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and neuropeptide Y altered angiogenic growth factor expression in vitro. Conclusions The regulation of angiogenic growth factor expression by neuropeptides suggests a novel role for neuropeptides in pulpal inflammation and repair.
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SourceType-Scholarly Journals-1
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ISSN:0099-2399
1878-3554
DOI:10.1016/j.joen.2009.03.005