Genetic polymorphism in RANK is associated with mandibular size

• Published in: Journal of orthodontics p. 1
• Main Authors: Küchler, Erika Calvano, Nascimento, Mariele Andrade do, Matsumoto, Mirian Aiko Nakane, Romano, Fabio Lourenço, da Silva, Raquel Assed Bezerra, Ayumi Omori, Marjorie, Antunes, Lívia Azeredo, Antunes, Leonardo Santos, da Silva, Léa Assed Bezerra, Nelson-Filho, Paulo
• Format: Journal Article
• Language: English
• Published: England 03.07.2018
• Subjects: Gene; polymorphisms; mandible and maxilla
• ISSN: 1465-3133
• DOI: 10.1080/14653125.2018.1476018

The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans. DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM-A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism. School of Dentistry of Ribeirão Preto, University of São Paulo. A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study. The polymorphism in RANK was associated with a higher Go-Pg measurement (p = .039). In the multivariate analysis, adjusted for age and gender, the polymorphism in RANK was associated with Go-Pg (p = .017) and Co-Gn (p = .043). The polymorphism rs3826620 in RANK is associated with the mandibular size.