Subsite-Specific Colorectal Cancer Incidence Rates and Stage Distributions among Asians and Pacific Islanders in the United States, 1995 to 1999
Objective: This study examined subsite-specific colorectal cancer incidence rates and stage distributions for Asians and Pacific Islanders (API) and compared the API data with data for Whites and African Americans. Methods: Data included 336,798 invasive colorectal cancer incident cases for 1995 to...
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Published in | Cancer epidemiology, biomarkers & prevention Vol. 13; no. 7; pp. 1215 - 1222 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia, PA
American Association for Cancer Research
01.07.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Objective: This study examined subsite-specific colorectal cancer incidence rates and stage distributions for Asians and Pacific
Islanders (API) and compared the API data with data for Whites and African Americans. Methods: Data included 336,798 invasive
colorectal cancer incident cases for 1995 to 1999 from 23 population-based central cancer registries, representing about two
thirds of API population in the United States. Age-adjusted rates, using the 2000 U.S. standard population, and age-specific
rates and stage distributions were computed by anatomic subsite, race, and gender. All rates were expressed per 100,000. SEs
and rate ratios were calculated for rate comparison. A significance level of 0.05 was used for all analyses. Results: Overall,
age-adjusted colorectal cancer incidence rates were significantly lower in API than in Whites and African Americans across
anatomic subsites, particularly for proximal colon cancer in which rates were 40% to 50% lower in API males and females. Exception
to this pattern was the significantly (10%) higher rectal cancer incidence rate in API males than in African American males.
The incidence patterns by anatomic subsite within API differed from those of Whites and African Americans. Among API, the
rate of rectal cancer (19.2 per 100,000) was significantly higher than the rates of proximal (15.2 per 100,000) and distal
(17.7 per 100,000) colon cancers in males, with little variations in rates across anatomic subsites in females. In contrast,
among White and African American males and females, proximal colon cancer rates were over 25% higher than the rates of distal
colon and rectal cancers. Increases in age-specific rates with advancing age were more striking for proximal colon cancer
than for distal colon and rectal cancers in Whites and African Americans, while age-specific rates were very similar for different
subsites in API with parallel increases with advancing age, especially in API males. Similar to Whites and African Americans,
in API, proximal colon cancers (32% to 35%) were also less likely to be diagnosed with localized stage compared with distal
colon (38% to 42%) and rectal (44% to 52%) cancers. Conclusion: The patterns of subsite-specific colorectal cancer incidence
in API, especially API males, differ from those of Whites and African Americans. Similar to Whites and African Americans,
lower percentage of localized disease in API for proximal colon cancer than for distal colon and rectal cancers was also observed. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.1215.13.7 |