Comparison of Pneumonia Severity Indices, qCSI, 4C-Mortality Score and qSOFA in Predicting Mortality in Hospitalized Patients with COVID-19 Pneumonia

• Published in: Journal of personalized medicine Vol. 12; no. 5; p. 801
• Main Authors: Kibar Akilli, Isil, Bilge, Muge, Uslu Guz, Arife, Korkusuz, Ramazan, Canbolat Unlu, Esra, Kart Yasar, Kadriye
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.05.2022; MDPI
• Subjects: Age; Blood pressure; Cardiovascular disease; Chronic illnesses; Comorbidity; Coronary vessels; Coronaviruses; COVID-19; Diabetes; Hospitalization; Hospitals; Hypertension; Influenza; Medical records; Mortality; Oxygen saturation; Pandemics; Patients; Pneumonia; Precision medicine; Sepsis; Severe acute respiratory syndrome coronavirus 2; Statistical analysis; Vein & artery diseases; severity; mortality; prediction; COVID-19 pneumonia; risk scores; prognosis
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm12050801

This is a retrospective and observational study on 1511 patients with SARS-CoV-2, who were diagnosed with COVID-19 by real-time PCR testing and hospitalized due to COVID-19 pneumonia. 1511 patients, 879 male (58.17%) and 632 female (41.83%) with a mean age of 60.1 ± 14.7 were included in the study. Survivors and non-survivors groups were statistically compared with respect to survival, discharge, ICU admission and in-hospital death. Although gender was not statistically significant different between two groups, 80 (60.15%) of the patients who died were male. Mean age was 72.8 ± 11.8 in non-survivors vs. 59.9 ± 14.7 in survivors (p < 0.001). Overall in-hospital mortality was found to be 8.8% (133/1511 cases), and overall ICU admission was 10.85% (164/1511 cases). The PSI/PORT score of the non-survivors group was higher than that of the survivors group (144.38 ± 28.64 versus 67.17 ± 25.63, p < 0.001). The PSI/PORT yielding the highest performance was the best predictor for in-hospital mortality, since it incorporates the factors as advanced age and comorbidity (AUROC 0.971; % 95 CI 0.961−0.981). The use of A-DROP may also be preferred as an easier alternative to PSI/PORT, which is a time-consuming evaluation although it is more comprehensive.