The Heart is a Target Organ for Androgen

Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 207; no. 4432; pp. 775 - 777
Main Authors McGill, H. C., Anselmo, V. C., Buchanan, J. M., Sheridan, P. J.
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 15.02.1980
Subjects
Androgen receptors
Androgens
Androgens - metabolism
Animals
Coronary Disease - etiology
Cytosol
Dihydrotestosterone - metabolism
Estradiol - metabolism
Estrogens
Female
Haplorhini
Heart
Kinetics
Macaca mulatta
Men
Myocardium
Myocardium - metabolism
Papio
Receptors
Receptors, Androgen - metabolism
Receptors, Steroid - metabolism
Sex Factors
Steroids
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Summary:Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known, the presence of this receptor suggests that sex steroid hormones may affect myocardial function directly and may explain some of the peculiar differences in heart disease between men and women.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.6766222