Periconiasin G, a new cytochalasan with unprecedented 7/6/5 tricyclic ring system from the endophytic fungus Periconia sp

[Display omitted] Two new cytochalasans, periconiasin G (1) and periconiasin H (2) were isolated from endophytic fungus Periconia sp. F-31. Compound 1 is the first cytochalasan with a 7/6/5 tricyclic ring system, and compound 2 possesses a rare sulfoxide group. Their structures including absolute co...

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Published inTetrahedron letters Vol. 57; no. 7; pp. 796 - 799
Main Authors Zhang, Dewu, Tao, Xiaoyu, Liu, Jimei, Chen, Ridao, Zhang, Min, Li, Li, Fang, Xiaomei, Yu, Li-Yan, Dai, Jungui
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 17.02.2016
Elsevier
Subjects
Chemistry
Chemistry, Organic
Cytochalasan
Endophytic fungus
Human immunodeficiency virus
Periconia
Periconiasin
Physical Sciences
Science & Technology
Cytochalasan
Periconiasin
Periconia
Endophytic fungus
SYNTHASE
CELLS
GENE-CLUSTER
CHAETOMIUM-GLOBOSUM
CHAETOGLOBOSIN
DERIVATIVES
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Summary:[Display omitted] Two new cytochalasans, periconiasin G (1) and periconiasin H (2) were isolated from endophytic fungus Periconia sp. F-31. Compound 1 is the first cytochalasan with a 7/6/5 tricyclic ring system, and compound 2 possesses a rare sulfoxide group. Their structures including absolute configurations were elucidated by extensive spectroscopic analyses and ECD calculations. A possible biogenetic pathway for these two compounds was proposed. Compound 1 showed weak anti-HIV activity with IC50 value of 67.0μM.
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.01.030