Malignant ascites: Systematic review and guideline for treatment

A guideline on the management of symptomatic malignant ascites by abdominal paracentesis, diuretics and peritoneovenous shunting, based on a systematic review of the literature is presented. Thirty-two relevant studies were identified. None were randomized control trials, one was a non-randomized op...

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Bibliographic Details
Published inEuropean journal of cancer (1990) Vol. 42; no. 5; pp. 589 - 597
Main Authors Becker, Gerhild, Galandi, Daniel, Blum, Hubert E.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.03.2006
Elsevier
Subjects
Ascites
Ascites - etiology
Ascites - therapy
Biological and medical sciences
Diuretics
Diuretics - therapeutic use
Humans
Medical sciences
Neoplasms
Neoplasms - complications
Neoplasms - therapy
Paracentesis
Paracentesis - methods
Peritoneovenous shunt
Peritoneovenous Shunt - methods
Pharmacology. Drug treatments
Tumors
Diuretics
Ascites
Peritoneovenous shunt
Neoplasms
Paracentesis
Shunt
Pharmacology
Malignant tumor
Recommendation
Diuretic
Cancerology
Treatment
Abdominal disease
Malignant effusion
Ascites Neoplasms Paracentesis Diuretics Peritoneovenous shunt
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Summary:A guideline on the management of symptomatic malignant ascites by abdominal paracentesis, diuretics and peritoneovenous shunting, based on a systematic review of the literature is presented. Thirty-two relevant studies were identified. None were randomized control trials, one was a non-randomized open controlled trial, five were cohort studies or prospective uncontrolled trials, 26 studies were non-analytic studies like case series. Although paracentesis, diuretics and shunting are commonly used procedures, the evidence is weak. Available data show good, although temporary effect of paracentesis on symptom relief. Fluid withdrawal speed and concurrent intravenous hydration is not sufficiently studied. Peritoneovenous shunts can control ascites in patients with malignant ascites, but have to be balanced by the potential risks of this procedure. The available data about diuretics in treatment of malignant ascites are controversial. The use of diuretics therefore should be considered in all patients, but has to be evaluated individually.
Bibliography:SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-2
ObjectType-Instructional Material/Guideline-4
ObjectType-Feature-5
ObjectType-Undefined-1
ObjectType-Article-3
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2005.11.018