PLASMA CONCENTRATION OF MORPHINE AFTER I.M., EXTRADURAL AND INTRATHECAL ADMINISTRATION

Seventeen patients received morphine 0.2 mgkg-1 in a 10% dextrose solution i.m. (n = 5), extradurally (n = 6) and intrathecally (n = 6) for pain after operation. Morphine was measured in plasma by radioimmunoassay. Plasma immunoreactive morphine concentration was significantly less after intrathecal...

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 53; no. 9; pp. 911 - 913
Main Authors CHAUVIN, M., SAMII, K., SCHERMANN, J.M., SANDOUK, P., BOURDON, R., VIARS, P.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.1981
Oxford University Press
Subjects
Absorption
Epidural Space
Humans
Injections
Injections, Intramuscular
Injections, Spinal
Morphine - administration & dosage
Morphine - blood
Pain, Postoperative - drug therapy
Time Factors
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Summary:Seventeen patients received morphine 0.2 mgkg-1 in a 10% dextrose solution i.m. (n = 5), extradurally (n = 6) and intrathecally (n = 6) for pain after operation. Morphine was measured in plasma by radioimmunoassay. Plasma immunoreactive morphine concentration was significantly less after intrathecal administration than after intrathecal administration than after i jn. and extradural administration(P<0.05) at 2, 10, 15 and 30 min. We conclude that morphine given extradurally has a greater initial rate of vascular absorption than morphine given intrathecally and is similar to that observed after i.m. administration.
Bibliography:ark:/67375/HXZ-D0T0FTMS-C
ArticleID:53.9.911
istex:E8C15197EDB8BA3160C9EEC62FF3D7DDB1C90D2F
Correspondence to K. S.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/53.9.911