ASSESSMENT OF THE ALLERGENIC POTENTIAL OF ALTHESIN AND ITS CONSTITUENTS

The pharmaceutical formulation of Althesin was shown to have a weak allergenic potential in the guineapig maximization test. Alphadolone and alphaxalone acetate were found to be devoid of such potential, while the status of Cremophor EL remained equivocal.

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 55; no. 8; pp. 715 - 717
Main Authors TACHON, P., DESCOTES, J., LASCHI-LOQUERIE, A., GUILLOT, J.P., EVREUX, J.C.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.1983
Oxford University Press
Subjects
Alfaxalone Alfadolone Mixture - immunology
Anesthetics - immunology
Animals
Drug Hypersensitivity - immunology
Female
Glycerol - analogs & derivatives
Glycerol - immunology
Guinea Pigs
Intradermal Tests
Male
Pregnanediones - immunology
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Summary:The pharmaceutical formulation of Althesin was shown to have a weak allergenic potential in the guineapig maximization test. Alphadolone and alphaxalone acetate were found to be devoid of such potential, while the status of Cremophor EL remained equivocal.
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content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/55.8.715