Alkaloids from an algicolous strain of Talaromyces sp

Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf- 16 included two naturally occurring alkaloids, 2-[（S）-hydroxy（phenyl）methyl]-3-mcthylquinazolin-4（3H）- one （la） and 2-[（R）-hydroxy（phenyl）methyl]-3-methylquinazolin-4（3H）-one （lb）, that were identified f...

Full description

Saved in:
Bibliographic Details
Published inChinese journal of oceanology and limnology Vol. 34; no. 2; pp. 367 - 371
Main Author 杨海滨 李昉 季乃云
Format Journal Article
LanguageEnglish
Published Heidelberg Science Press 01.03.2016
Springer Nature B.V
Subjects
Algae
Alkaloids
Aquatic crustaceans
Artemia
Bio-assays
Bioassays
Biological activity
Chemical compounds
Chromatography
Column chromatography
Decapoda
Earth and Environmental Science
Earth Sciences
Enantiomers
Endophytes
Fungi
Marine
Oceanography
Penaeidae
Quantum chemistry
S3 Sustainable Utilization of Coastal Bioresources
spectroscopy
Staphylococcus aureus
Talaromyces
toxicity
内生真菌
化合物
柱色谱法
海藻
生物碱
菌株
量子化学计算
金黄色葡萄球菌
chiral separation
bioactivity
alkaloid
quantum chemical calculation
sp
Online AccessGet full text
ISSN0254-4059
2096-5508
1993-5005
2523-3521
DOI10.1007/s00343-015-4316-2

Cover

More Information
Summary:Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf- 16 included two naturally occurring alkaloids, 2-[（S）-hydroxy（phenyl）methyl]-3-mcthylquinazolin-4（3H）- one （la） and 2-[（R）-hydroxy（phenyl）methyl]-3-methylquinazolin-4（3H）-one （lb）, that were identified for the first time. In addition, seven known compounds （2-8） were obtained from the culture. Following chiral column chromatography, compounds la and lb were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3-6 could inhibit Staphylococcus aureus.
Bibliography:Talaromyces sp.; alkaloid; chiral separation; quantum chemical calculation; bioactivity
37-1150/P
Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf- 16 included two naturally occurring alkaloids, 2-[（S）-hydroxy（phenyl）methyl]-3-mcthylquinazolin-4（3H）- one （la） and 2-[（R）-hydroxy（phenyl）methyl]-3-methylquinazolin-4（3H）-one （lb）, that were identified for the first time. In addition, seven known compounds （2-8） were obtained from the culture. Following chiral column chromatography, compounds la and lb were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3-6 could inhibit Staphylococcus aureus.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0254-4059
2096-5508
1993-5005
2523-3521
DOI:10.1007/s00343-015-4316-2