MiR-29a : a potential therapeutic target and promising biomarker in tumors

• Published in: Bioscience reports Vol. 38; no. 1
• Main Authors: Wang, Jin-Yan, Zhang, Qian, Wang, Dan-Dan, Yan, Wei, Sha, Huan-Huan, Zhao, Jian-Hua, Yang, Su-Jin, Zhang, He-da, Hou, Jun-Chen, Xu, Han-Zi, He, Yun-Jie, Hu, Jia-Hua, Zhong, Shan-Liang, Tang, Jin-Hai
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd The Biochemical Society 28.02.2018; Portland Press Ltd
• Subjects: 3' Untranslated regions; Angiogenesis; Antigens; Apoptosis; Apoptosis - genetics; Binding; Biomarkers; Biomarkers, Tumor - genetics; Cancer; Cell adhesion & migration; Cell cycle; Cell differentiation; Cell division; Cell growth; Cell proliferation; Cell Proliferation - genetics; Cyclin-dependent kinases; Disease resistance; Drug resistance; Fibrosis; Genes; Heat shock proteins; Humans; Kinases; Leukemia; Liver cancer; Liver diseases; Lung cancer; Medical prognosis; Metastases; Metastasis; MicroRNAs - genetics; Molecular Targeted Therapy; Neoplasms; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Non-coding RNA; Pancreatic cancer; Phosphatase; Post-transcription; Review; Therapeutic targets; Tuberculosis; Tumor necrosis factor-TNF; Tumorigenicity; Tumors; Vascular endothelial growth factor; metastases; microRNA; cancer; proliferation; biomarkers; miR-29a
• ISSN: 0144-8463; 1573-4935
• DOI: 10.1042/BSR20171265

MiRNAs, small non-coding RNA molecules, were recognized to be associated with the incidence and development of diverse neoplasms. MiRNAs were small non-coding RNAs that could regulate post-transcriptional level by binding to 3'-UTR of target mRNAs. Amongst which, was demonstrated that it had significant impact on oncogenicity in various neoplasms through binding to critical genes which enhanced or inhibited the progression of cancers. participated in kinds of physiological and pathological processes, including virus replication, cell proliferation, differentiation, apoptosis, fibrosis, angiogenesis, tumorigenicity, metastasis, drug-resistance, and so on. According to its sufficient sensitivity and specificity, many studies showed that might serve as a potential therapeutic target and promising biomarker in various tumors. In this review, we discussed the functions of and its potential application in the diagnosis, treatment and stages of carcinoma, which could provide additional insight to develop a novel therapeutic strategy.