THE NATURE OF GENTAMICIN-INDUCED NEUROMUSCULAR BLOCK

Gentamicin in concentrations of 0.05–0.2 mmol litre−1 blocked neuromuscular transmission in the toad sartorius nerve-muscle preparation by decreasing the release of transmitter. In concentrations of 0.5–1 mmol litre−1 it decreased the amplitude of the miniature end-plate current by a curare-like act...

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 52; no. 3; pp. 325 - 326
Main Author TORDA, T.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.1980
Oxford University Press
Subjects
Animals
Bufo marinus
Depression, Chemical
Gentamicins - pharmacology
In Vitro Techniques
Membrane Potentials - drug effects
Neuromuscular Junction - drug effects
Neuromuscular Junction - physiology
Synaptic Transmission - drug effects
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Summary:Gentamicin in concentrations of 0.05–0.2 mmol litre−1 blocked neuromuscular transmission in the toad sartorius nerve-muscle preparation by decreasing the release of transmitter. In concentrations of 0.5–1 mmol litre−1 it decreased the amplitude of the miniature end-plate current by a curare-like action, without affecting the mean open channel lifetime.
Bibliography:ArticleID:52.3.325
Present address: Division of Anaesthesia and Intensive Care, Prince Henry Hospital, Little Bay, N.S.W. 2036, Australia
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/52.3.325