Similar mechanisms formed ring markers containing chromosome 12 pericentromeric region in two patients with therapy-related acute myeloid leukemia

Abstract Two cases of therapy-related acute myeloid leukemia showed complex karyotypes, including a small ring and a larger D-chromosome. Multicolor fluorescence in situ hybridization and bacterial artificial chromosome and fosmid clones showed that both ring chromosomes were composed entirely of ma...

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Published inCancer genetics and cytogenetics Vol. 181; no. 2; pp. 131 - 137
Main Authors Impera, Luciana, Albano, Francesco, Mancini, Marco, Aventin, Ana, Rocchi, Mariano, Storlazzi, Clelia Tiziana
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2008
Subjects
Chromosomes, Artificial, Bacterial
Chromosomes, Human, Pair 12
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute - etiology
Leukemia, Myeloid, Acute - genetics
Male
Medical Education
Middle Aged
Models, Genetic
Ring Chromosomes
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Summary:Abstract Two cases of therapy-related acute myeloid leukemia showed complex karyotypes, including a small ring and a larger D-chromosome. Multicolor fluorescence in situ hybridization and bacterial artificial chromosome and fosmid clones showed that both ring chromosomes were composed entirely of material excised from chromosome 12. The deleted segment of 12 was found fused to the short arm of a D-group chromosome. We hypothesized that similar mechanisms were involved in both rearrangements. A fusion at the short arms of chromosome 12 and a D-group chromosome was accompanied by excision and ligation of the chromosome 12 pericentromeric region to form a small ring chromosome.
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ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2007.11.013