Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have be...

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Published inFrontiers in immunology Vol. 12
Main Authors Zhou, Xiaoli, Zhou, Ya-Na, Ali, Ashaq, Liang, Cuiqin, Ye, Zhiqin, Chen, Xiaomin, Zhang, Qing, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Luo, Jihong, Li, Wei, Zhou, Kun, Cao, Shanshan, Zhang, Xiaowei, Li, Xiao-Dong, Zhang, Xian-En, Cui, Zongqiang, Men, Dong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 28.07.2021
Subjects
aqueous humor
COVID-19
glaucoma
Immunology
immunostaining
SARS-CoV-2
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Abstract The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.
AbstractList The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.
Author Zhang, Xian-En
Zhou, Ya-Na
Ali, Ashaq
Liang, Cuiqin
Sun, Xinyi
Zhou, Kun
Li, Xiao-Dong
Luo, Jihong
Zhang, Xiaowei
Li, Wei
Zhang, Qian
Cao, Shanshan
Deng, Lihua
Zhou, Xiaoli
Chen, Xiaomin
Ye, Zhiqin
Cui, Zongqiang
Men, Dong
Zhang, Qing
AuthorAffiliation 1 Hubei Province Hospital of Traditional Chinese Medicine , Wuhan , China
2 State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences , Wuhan , China
4 National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing , China
3 University of Chinese Academy of Sciences , Beijing , China
5 First Clinical College, Hubei University of Chinese Medicine , Wuhan , China
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Copyright Copyright © 2021 Zhou, Zhou, Ali, Liang, Ye, Chen, Zhang, Deng, Sun, Zhang, Luo, Li, Zhou, Cao, Zhang, Li, Zhang, Cui and Men 2021 Zhou, Zhou, Ali, Liang, Ye, Chen, Zhang, Deng, Sun, Zhang, Luo, Li, Zhou, Cao, Zhang, Li, Zhang, Cui and Men
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Notes Edited by: Christiane Moog, Institut National de la Santé et de la Recherche Médicale (INSERM), France
These authors have contributed equally to this work
This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology
Reviewed by: Willy A Valdivia-Granda, Orion Integrated Biosciences, United States; Sheikh Rahman, Emory University, United States
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SubjectTerms aqueous humor
COVID-19
glaucoma
Immunology
immunostaining
SARS-CoV-2
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Title Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma
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