Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have be...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 12
Main Authors Zhou, Xiaoli, Zhou, Ya-Na, Ali, Ashaq, Liang, Cuiqin, Ye, Zhiqin, Chen, Xiaomin, Zhang, Qing, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Luo, Jihong, Li, Wei, Zhou, Kun, Cao, Shanshan, Zhang, Xiaowei, Li, Xiao-Dong, Zhang, Xian-En, Cui, Zongqiang, Men, Dong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 28.07.2021
Subjects
aqueous humor
COVID-19
glaucoma
Immunology
immunostaining
SARS-CoV-2
Online AccessGet full text

Cover

More Information
Summary:The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.
Bibliography:Edited by: Christiane Moog, Institut National de la Santé et de la Recherche Médicale (INSERM), France
These authors have contributed equally to this work
This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology
Reviewed by: Willy A Valdivia-Granda, Orion Integrated Biosciences, United States; Sheikh Rahman, Emory University, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.701295