Synthesis and Pharmacological Evaluation of Novel Selenoethers Glycerol Derivatives for the Treatment of Pain and Inflammation: Involvement of Nitrergic and Glutamatergic Systems

In the present study, the synthesis of new selenoethers from nucleophilic substitution reaction between organyl halides and nucleophilic species of selenium generated in situ was demonstrated. After, this method was applied for the synthesis of pyridylselenides glycerol derivatives 9b and 9c and the...

Full description

Saved in:
Bibliographic Details
Published inApplied biochemistry and biotechnology Vol. 187; no. 4; pp. 1398 - 1423
Main Authors Perin, Gelson, Goulart, Helen A., Soares, Liane K., Peglow, Thiago J., Schumacher, Ricardo F., Pinz, Mikaela P., Reis, Angélica S., Luchese, Cristiane, Wilhelm, Ethel A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2019
Springer Nature B.V
Subjects
Acute toxicity
Biochemistry
Biotechnology
Chemical synthesis
Chemistry
Chemistry and Materials Science
Derivatives
Glutamatergic transmission
Glycerol
Halides
Inflammation
Latency
Oxidative stress
Pain
Pain perception
Parameter modification
Pharmacology
Selenium
Substitution reactions
Toxicity
Nociception
3-Aminopyridil compounds
Selenoether
Glycerol
Glutamate
Nitric oxide
Online AccessGet full text

Cover

More Information
Summary:In the present study, the synthesis of new selenoethers from nucleophilic substitution reaction between organyl halides and nucleophilic species of selenium generated in situ was demonstrated. After, this method was applied for the synthesis of pyridylselenides glycerol derivatives 9b and 9c and the antinociceptive and anti-inflammatory effects, as well as, acute toxicity were evaluated. In the formalin test, the compound 9b caused a reduction in licking time in both phases. Compounds 9b and 9c increased the latency to response in the hot-plate test and reduced the licking time induced by glutamate. Our results revealed the involvement of the nitrergic and/or glutamatergic pathways in the antinociceptive action of the compounds. Additionally, 9b and 9c did not cause any toxicity signals and oxidative stress parameters were not modified by treatments. Here, it was developed an alternative and efficient method for the synthesis of selenoethers glycerol derivatives. Furthermore, we demonstrated that this class is indeed interesting for the research of new drugs. Graphical Abstract ᅟ
ISSN:0273-2289
1559-0291
DOI:10.1007/s12010-018-2887-z