Telomeres as hotspots for innate immunity and inflammation

Aging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a subject of ongoing research, there are several cel...

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Bibliographic Details
Published inDNA repair Vol. 133; p. 103591
Main Authors Nassour, Joe, Przetocka, Sara, Karlseder, Jan
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2024
Subjects
Aging - genetics
Cellular Senescence
Humans
Immunity, Innate
Inflammation
Telomere
Aging
Telomeres
Innate immunity
Inflammation
Genome stability
Cancer
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Summary:Aging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a subject of ongoing research, there are several cellular and molecular hallmarks that contribute to this biological process. This review focuses on two factors, namely telomere dysfunction and inflammation, which have emerged as crucial contributors to the aging process. We aim to discuss the mechanistic connections between these two distinct hallmarks and provide compelling evidence highlighting the loss of telomere protection as a driver of pro-inflammatory states associated with aging. By reevaluating the interplay between telomeres, innate immunity, and inflammation, we present novel perspectives on the etiology of aging and its associated diseases.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1568-7864
1568-7856
1568-7856
DOI:10.1016/j.dnarep.2023.103591