Intravenous lidocaine pretreatment with venous occlusion for reducing microemulsion propofol induced pain: Comparison of three doses of lidocaine

• Published in: Journal of international medical research Vol. 42; no. 2; pp. 368 - 375
• Main Authors: Kim, Dae Hee, Chae, Yun Jeong, Chang, Hyuk Soo, Kim, Jin A, Joe, Han Bum
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2014; Sage Publications
• Subjects: Administration, Intravenous; Adult; Anesthetics, Intravenous - administration & dosage; Anesthetics, Local - administration & dosage; Biological and medical sciences; Double-Blind Method; Female; Humans; Lidocaine - administration & dosage; Lidocaine - therapeutic use; Male; Medical sciences; Middle Aged; Pain - drug therapy; Pain Management; Pain Measurement; Pharmacology. Drug treatments; Propofol - administration & dosage; Propofol - adverse effects; Treatment Outcome; Young Adult; lidocaine pretreatment; microemulsion propofol; Injection pain; Intravenous administration; Induced pain; Anticonvulsant; Injection; Antiarrhythmic agent; Local anesthetic; General anesthetic; Organic amide; Propofol; Pretreatment; Lidocaine; Microemulsion; Comparative study
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060513507391

Objective Pretreatment with intravenous 40 mg or 0.5 mg/kg lidocaine with venous occlusion is recommended to prevent pain following injection of lipid emulsion propofol. This approach is not sufficient to prevent pain from the injection of microemulsion propofol. The present study investigated whether a higher dose of lidocaine pretreatment with venous occlusion would be more effective for reducing pain following injection of microemulsion propofol compared with 40 mg lidocaine. Methods Patients undergoing elective surgery were randomly assigned to one of three groups: pretreatment with 40 mg (group L40), 60 mg (group L60) or 80 mg (group L80) lidocaine intravenously with venous occlusion, followed by injection with microemulsion propofol 1 min later. Pain was assessed on a four-point scale (severe, moderate, mild, none) based on physical responses to the injection. Results A total of 68 patients were included in the final analysis. Pain severity and incidence were significantly lower in patients in group L60 and L80 compared with patients in group L40. There were no statistically significant differences in pain incidence or severity between group L60 and group L80. Conclusions Pretreatment with 60 mg lidocaine intravenously with venous occlusion may be the most effective minimum dose for reducing injection pain following microemulsion propofol administration for induction of anaesthesia.