Curcumin and its analogues: a potential natural compound against HIV infection and AIDS
No safe and effective cure currently exists for human immunodeficiency virus (HIV). However, antiretroviral therapy can prolong the lives of HIV patients and lowers the secondary infections. Natural compounds, which are considered to be pleiotropic molecules, could be useful against HIV. Curcumin, a...
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| Published in | Food & function Vol. 6; no. 11; pp. 3412 - 3419 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.11.2015
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| Subjects | |
| Online Access | Get full text |
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| Summary: | No safe and effective cure currently exists for human immunodeficiency virus (HIV). However, antiretroviral therapy can prolong the lives of HIV patients and lowers the secondary infections. Natural compounds, which are considered to be pleiotropic molecules, could be useful against HIV. Curcumin, a yellow pigment present in the spice turmeric (
Curcuma longa
), can be used for the treatment of several diseases including HIV-AIDS because of its antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial nature. In this review we have summarized that how curcumin and its analogues inhibit the infection and replication of viral genes and prevent multiplicity of HIV. They are inhibitors of HIV protease and integrase. Curcumin also inhibits Tat transactivation of the HIV1-LTR genome, inflammatory molecules (interleukins, TNF-α, NF-κB, COX-2) and HIV associated various kinases including tyrosine kinase, PAK1, MAPK, PKC, cdk and others. In addition, curcumin enhances the effect of conventional therapeutic drugs and minimizes their side effects.
No safe and effective cure currently exists for human immunodeficiency virus (HIV). |
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| Bibliography: | Dr Amit Kumar Tyagi received his PhD degree in Applied Microbiology from Indian Institute of Technology Delhi, New Delhi, India where he studied the antimicrobial potential of different phytochemicals against food spoiling and disease causing microorganisms in and in vitro tumor models. Before joining his PhD program, Dr Prasad received support from the National Eligibility Test (CSIR - UGC-NET), the Graduate Aptitude Test in Engineering (GATE) and the Indian Council of Medical Research Junior Research Fellowship (ICMR-JRF) awarded by Govt. of India. After his PhD, he joined as a Post-doctoral Fellow in the Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, USA. His expertise is in the area of molecular biology with particular reference to molecular mechanisms of signal transduction in tumor cells. Dr Prasad has discovered a number of phytochemicals with chemo-preventive effects against a variety of cancers and their mechanism of action. The current research focus of Dr Prasad is on investigating the effects of chemo-preventive and chemotherapeutic agents among natural products that could suppress the activation of pro-inflammatory transcription factors NF-κB and STAT3. Besides these, Dr Prasad's work also focuses on the effect of natural compounds on death receptor pathways, bone loss and chemosensitization of tumor cells. He has numerous national and international publications, and abstracts indexed international conferences. He is also a member of the editorial board of various reputed journals. in vivo food models. During his PhD, he was supported by Council for Scientific and Industrial Research-University Grant Commission (CSIR-UGC) and awarded the European grant 'Erasmus Mundus Corporation Window' for conducting part of his thesis work in University of Bologna, Italy. His work at The University of Texas MD Anderson Cancer Center revealed that TNF exhibits pro-inflammatory activities and may mediate carcinogenesis through the activation of a transcription factor, NF-κB. The gene products regulated by NF-κB have now been linked to cellular transformation, tumor cell survival, proliferation, invasion, angiogenesis, metastasis, chemoresistance, and radioresistance. Mostly carcinogens, tumor promoters, growth factors, inflammatory agents, chemotherapeutic agents, radiation, viruses, bacteria, cigarette smoke, alcohol and other lifestyle factors activate NF-κB and another transcription factor, STAT3. Dr Tyagi's research group is working on unraveling whether safe and multi-targeting chemopreventive agents derived from natural resources can suppress NF-κB and STAT3 pathways and suppress tumorigenesis. At present, he is serving as editorial board member, guest associate editor, editor in chief in various international journals. Dr Sahdeo Prasad obtained his Ph.D. (Biotechnology), CSJM University, Kanpur, India and Indian Institute of Toxicology Research (CSIR), Lucknow, India. During his doctoral research program, he extensively worked on signal transduction pathways in both ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
| ISSN: | 2042-6496 2042-650X |
| DOI: | 10.1039/c5fo00485c |