Heterochronous Metastases of Lung Adenocarcinoma to Pancreas and Liver: A Case Report from Pathological Perspectives

Immunohistochemistry (IHC) is a vital tool to distinguish tumor metastases from primary lesions in addition to morphologic analysis. In this study, a 64-year- old female with a past surgical history of lung adenocarcinoma 11 years ago was presented with recurrence of liver nodular lesions after mult...

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Published inOncoTargets and therapy Vol. 14; pp. 4269 - 4273
Main Authors Zhang, Bo, Hu, Qida, Yu, Jiajie, Wang, Junsen, Yang, Hanjin, Lou, Jiongbo, Cai, Guoying, Huang, Haifeng, Xu, Mengqiu, Xiao, Zhaoying, Zhang, Yun
Format Journal Article
LanguageEnglish
Published Macclesfield Dove Medical Press Limited 31.07.2021
Taylor & Francis Ltd
Dove
Subjects
Adenocarcinoma
Biomarkers
Biopsy
Case Report
Chemotherapy
Consent
Diagnosis
Immunohistochemistry
Liver
Lung cancer
Lungs
Lymphatic system
Medical prognosis
Metastases
Metastasis
Morphology
Mutation
Pancreas
Pancreatic cancer
Pancreaticoduodenectomy
Pathology
Patients
Phenotypes
Tumors
China
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Summary:Immunohistochemistry (IHC) is a vital tool to distinguish tumor metastases from primary lesions in addition to morphologic analysis. In this study, a 64-year- old female with a past surgical history of lung adenocarcinoma 11 years ago was presented with recurrence of liver nodular lesions after multiple surgical procedures, including the Whipple procedure for pancreatic head adenocarcinoma and cytoreductive surgery for liver metastasis. Liver biopsy and review of the previous specimens, based on IHC analyses, suggested heterochronous metastases of lung adenocarcinoma to the digestive systems in a long-time span, instead of primary pancreatic adenocarcinoma. This case demonstrates the potential for misdiagnoses from morphologic analysis alone and suggests the necessity of IHC analyses to avoid misjudgment on tumor phenotypes, when a previous oncologic history is presented. Keywords: heterochronous metastases, lung adenocarcinoma, immunohistochemistry
Bibliography:These authors contributed equally to this work
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S314385