CRITICAL FLICKER FREQUENCY AFTER SMALL DOSES OF METHOHEXITONE, DIAZEPAM AND SODIUM 4-HYDROXYBUTYRATE

Statistically significant depression of critical flicker frequency has been measured following the intravenous injection of methohexitone (0.15 mg/kg), diazepam (0.05 mg/kg) and sodium 4-hydroxybutyrate (10 mg/kg). In the cases of methohexitone and diazepam the maximal measured changes (4.73 per cen...

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 43; no. 2; pp. 110 - 112
Main Authors GROVE-WHITE, I.G., KELMAN, G.R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.1971
Oxford University Press
Subjects
Adult
Dark Adaptation
Diazepam - administration & dosage
Diazepam - pharmacology
Female
Flicker Fusion - drug effects
Humans
Hydroxybutyrates - administration & dosage
Hydroxybutyrates - pharmacology
Injections, Intravenous
Light
Male
Methohexital - administration & dosage
Methohexital - pharmacology
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Summary:Statistically significant depression of critical flicker frequency has been measured following the intravenous injection of methohexitone (0.15 mg/kg), diazepam (0.05 mg/kg) and sodium 4-hydroxybutyrate (10 mg/kg). In the cases of methohexitone and diazepam the maximal measured changes (4.73 per cent and 7.07 per cent, respectively) occurred after 5 minutes and persisted for up to 90 minutes. After 4-hydroxybutyrate, depression was maximal at 15 minutes (4.32 per cent), but had disappeared by 30 minutes. No significant changes occurred after the injection of isotonic saline.
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ISSN:0007-0912
1471-6771
DOI:10.1093/bja/43.2.110