Role of Catechol-O-methyltransferase Val158Met Polymorphism on Transcranial Direct Current Stimulation in Swallowing

Transcranial direct current stimulation (tDCS) is one of the latest post-stroke dysphagia treatment modalities, and the effect of tDCS is known to be affected by various factors including genetic polymorphisms. However, the role of catechol-O-methyltransferase (COMT) polymorphisms on tDCS in swallow...

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Published inJournal of personalized medicine Vol. 12; no. 3; p. 488
Main Authors Hwang, Hyemi, Han, Yeonjae, Park, Geun-Young, Lee, Soohwan, Park, Hae-Yeon, Im, Sun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.03.2022
MDPI
Subjects
Brain-derived neurotrophic factor
Catechol
Catechol O-methyltransferase
Cortex (motor)
Dopamine
Dysphagia
Electrodes
Gene polymorphism
Genetic analysis
Magnetic fields
Methyltransferase
Motor evoked potentials
Polymorphism
Precision medicine
Stroke
Swallowing
Transcranial magnetic stimulation
Denmark
catechol-O-methyltransferase
dysphagia
genetic polymorphism
transcranial direct current stimulation
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Summary:Transcranial direct current stimulation (tDCS) is one of the latest post-stroke dysphagia treatment modalities, and the effect of tDCS is known to be affected by various factors including genetic polymorphisms. However, the role of catechol-O-methyltransferase (COMT) polymorphisms on tDCS in swallowing is unclear. In this prospective pilot study, we aim to explore the effect of tDCS on the swallowing cortex and subsequent swallowing motor function according to COMT polymorphism. Twenty-four healthy participants received either anodal tDCS or sham mode tDCS on the mylohyoid motor cortex at random order, after inhibitory repetitive transcranial magnetic stimulation (rTMS) for preconditioning. The primary outcome was the changes of mylohyoid-motor-evoked potentials (MH-MEP) amplitude in each COMT polymorphism group, from the post-inhibitory rTMS baseline state to immediate, 30, and 60 min after tDCS. The secondary outcomes were the changes in swallowing function. The results showed that COMT Val/Val polymorphism showed improvement across time in the MH-MEP amplitudes and triggering time of swallowing after tDCS, whereas COMT Met carrier group did not show significant changes of MH-MEP or swallowing function across time. This therapeutic response variability of tDCS in the mylohyoid motor system according to COMT polymorphism support the importance of genetic analysis in individualized dysphagia treatment.
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These authors contributed equally to this manuscript.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12030488