The role of platelets in sepsis: A review

Sepsis, a life-threatening condition characterized by organ dysfunction, results from a complex series of pathophysiological mechanisms including immune dysfunction, an uncontrolled inflammatory response, and coagulation abnormalities. It is a major contributor to global mortality and severe disease...

Full description

Saved in:
Bibliographic Details
Published inBiomolecules & Biomedicine Vol. 24; no. 4; pp. 741 - 752
Main Authors Xu, Xinxin, Wang, Yurou, Tao, Yiming, Dang, Wenpei, Yang, Bin, Li, Yongsheng
Format Journal Article
LanguageEnglish
Published Bosnia and Herzegovina Association of Basic Medical Sciences 01.08.2024
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Subjects
Activation
Animals
Biological markers
Biomarkers - blood
Blood Coagulation - physiology
Blood platelets
Blood Platelets - pathology
Blood Platelets - physiology
Development and progression
Drug therapy
Health aspects
Humans
Physiological aspects
Platelet Activation - physiology
Platelets, sepsis, inflammatory, coagulation
Review
Sepsis
Sepsis - blood
Sepsis - immunology
Sepsis - physiopathology
China
Online AccessGet full text

Cover

More Information
Summary:Sepsis, a life-threatening condition characterized by organ dysfunction, results from a complex series of pathophysiological mechanisms including immune dysfunction, an uncontrolled inflammatory response, and coagulation abnormalities. It is a major contributor to global mortality and severe disease development. Platelets, abundant in the circulatory system, are sensitive to changes in the body's internal environment and are among the first cells to respond to dysregulated pro-inflammatory and pro-coagulant reactions at the onset of sepsis. In the initial stages of sepsis, the coagulation cascade, inflammatory response, and endothelial tissue damage perpetually trigger platelet activation. These activated platelets then engage in complex inflammatory and immune reactions, potentially leading to organ dysfunction. Therefore, further research is essential to fully understand the role of platelets in sepsis pathology and to develop effective therapeutic strategies targeting the associated pathogenic pathways. This review delves into the involvement of platelets in sepsis and briefly outlines the clinical applications of associated biomarkers.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Xinxin Xu and Yurou Wang contributed equally to this work.
ISSN:2831-0896
2831-090X
2831-090X
DOI:10.17305/bb.2023.10135