Coupling of Histone and DNA Synthesis in the Somatic Cell Cycle
The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlatio...
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Published in | Science (American Association for the Advancement of Science) Vol. 215; no. 4528; pp. 79 - 81 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
The American Association for the Advancement of Science
01.01.1982
American Association for the Advancement of Science |
Subjects | |
Online Access | Get full text |
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Summary: | The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.7053561 |