Coupling of Histone and DNA Synthesis in the Somatic Cell Cycle

The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlatio...

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Published inScience (American Association for the Advancement of Science) Vol. 215; no. 4528; pp. 79 - 81
Main Authors Delegeane, Angelo M., Lee, Amy S.
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 01.01.1982
American Association for the Advancement of Science
Subjects
Animals
Cell Cycle
Cell growth
Cell Line
Cell lines
Cricetinae
Deoxyribose synthesis
DNA
DNA - biosynthesis
DNA Replication
Fibroblasts
Gels
Genetic mutation
HeLa cells
Histones
Histones - biosynthesis
Mutation
Somatic cells
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Summary:The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.7053561