Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp
Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectro...
Saved in:
| Published in | Marine drugs Vol. 22; no. 2; p. 78 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
03.02.2024
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds 6–10 and 16 exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated 7 displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent. |
|---|---|
| AbstractList | Eleven new brominated depsidones, namely spiromastixones U-Z5 (1-11) along with five known analogues (12-16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds 6-10 and 16 exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated 7 displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent.Eleven new brominated depsidones, namely spiromastixones U-Z5 (1-11) along with five known analogues (12-16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds 6-10 and 16 exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated 7 displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent. Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds 6–10 and 16 exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated 7 displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent. Eleven new brominated depsidones, namely spiromastixones U-Z5 ( - ) along with five known analogues ( - ), were isolated from a deep-sea-derived fungus sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds - and exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant (MRSA) and vancomycin-resistant (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent. |
| Author | Huang, Zequan Fan, Aili Chen, Shang Ren, Jinwei Lin, Wenhan Gao, Chenghai Liu, Dong Li, Zhiyong |
| Author_xml | – sequence: 1 givenname: Zequan surname: Huang fullname: Huang, Zequan – sequence: 2 givenname: Dong surname: Liu fullname: Liu, Dong – sequence: 3 givenname: Shang orcidid: 0000-0002-4874-2922 surname: Chen fullname: Chen, Shang – sequence: 4 givenname: Jinwei surname: Ren fullname: Ren, Jinwei – sequence: 5 givenname: Chenghai orcidid: 0000-0002-7524-8049 surname: Gao fullname: Gao, Chenghai – sequence: 6 givenname: Zhiyong orcidid: 0000-0001-9469-8857 surname: Li fullname: Li, Zhiyong – sequence: 7 givenname: Aili orcidid: 0000-0003-4738-0517 surname: Fan fullname: Fan, Aili – sequence: 8 givenname: Wenhan orcidid: 0000-0002-4978-4083 surname: Lin fullname: Lin, Wenhan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38393049$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkktv1TAQRi3UirYXNvwAFIkNQkoZZxwnXpY-oFKlLgpbookfxVdJHOyEx7_H5ZaCumFla3zmSJ5vjtjeFCbL2AsOx4gK3o6mqqACaNon7JBLCWUuN3v_3A_YUUpbAKxbJZ6yA2xRIQh1yD6_i2H0Ey3WFGd2Tt5kdyq---VLcTItvie92OhpKM6ds3pJhcsNBWXYzuWNpfIsP3_L3RfrdLum4mb2GaC0-B9Fmp-xfUdDss_vzw37dHH-8fRDeXX9_vL05KrUAtRSCgVUk1aGC4OVVb3AVreoFRHVWjqJrQMpOVJLzgghTQ9OatU40wJvCDfscuc1gbbdHP1I8WcXyHe_CyHedhQXrwfbSa5E9vFaN0IQ2r7qjQWJmiPvmx6z6_XONcfwdbVp6UaftB0GmmxYU5cHB6JWwOV_0UphTgbrps7oq0foNqxxykO5o0A1bZ1T2bCX99Taj9Y8_ORPYBl4swN0DClF6x4QDt3dNnR_twF_AdTZpBU |
| Cites_doi | 10.1016/j.bmcl.2018.04.066 10.3390/md13042526 10.1021/np5000457 10.1093/cid/ciaa1581 10.1021/ci400539q 10.1016/j.ejmech.2015.09.037 10.1021/jacs.2c08585 10.1021/acs.chemrev.6b00571 10.1002/ps.1829 10.1021/acsinfecdis.0c00913 10.1056/NEJM200012143432402 10.1038/s41598-020-71771-8 10.1002/cjoc.202200064 10.1002/cbic.200300619 10.1002/anie.202214379 10.1038/s41586-021-04265-w 10.2174/0929867003374138 10.1016/j.apsb.2023.05.036 10.1039/D1RA05736G 10.1021/ja00309a038 |
| ContentType | Journal Article |
| Copyright | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | AAYXX CITATION NPM 3V. 7T7 7TN 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI BKSAR C1K CCPQU DWQXO F1W FR3 FYUFA GHDGH GNUQQ H95 H99 HCIFZ K9. L.F L.G LK8 M0S M1P M7P P64 PCBAR PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 7S9 L.6 DOA |
| DOI | 10.3390/md22020078 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Industrial and Applied Microbiology Abstracts (Microbiology A) Oceanic Abstracts ProQuest - Health & Medical Complete保健、医学与药学数据库 ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection Proquest Central Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central ASFA: Aquatic Sciences and Fisheries Abstracts Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources ASFA: Marine Biotechnology Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts Aquatic Science & Fisheries Abstracts (ASFA) Professional ProQuest Biological Science Collection Health & Medical Collection (Alumni) Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts Earth, Atmospheric & Aquatic Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic AGRICOLA AGRICOLA - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database Aquatic Science & Fisheries Abstracts (ASFA) Professional ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Oceanic Abstracts Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ASFA: Aquatic Sciences and Fisheries Abstracts Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef Publicly Available Content Database AGRICOLA PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1660-3397 |
| ExternalDocumentID | oai_doaj_org_article_619463815c744a3eb2bde063c131b7b3 38393049 10_3390_md22020078 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: the National Key Research and Development Project grantid: 2022YFC2804500 – fundername: National Natural Science Foundation of China grantid: 81991525, 82173733 – fundername: China Ocean Mineral Resource R&D Association grantid: DY135-B-05 – fundername: the Ningbo Key Science and Technology Development Program grantid: 2022Z144, 2021Z046 – fundername: Open Funding Project of State Key Laboratory of Microbial Metabolism grantid: MMLKF22-02 |
| GroupedDBID | --- 29M 2WC 53G 5GY 5VS 7X7 88E 8CJ 8FE 8FH 8FI 8FJ AADQD AAHBH AAYXX ABUWG ACGFO ACIHN ACPRK ADBBV AEAQA AENEX AEUYN AFKRA AFRAH AFZYC AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BBNVY BCNDV BENPR BHPHI BKSAR BPHCQ BVXVI CCPQU CITATION CS3 D1J DIK DU5 E3Z EBD EDH F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IHR ITC KQ8 LK5 LK8 M1P M48 M7P M7R MK0 MODMG M~E O5R O5S OK1 OVT P2P PCBAR PGMZT PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO RNS RPM TR2 UKHRP XSB NPM PJZUB PPXIY PQGLB 3V. 7T7 7TN 7XB 8FD 8FK AZQEC C1K DWQXO F1W FR3 GNUQQ H95 H99 K9. L.F L.G P64 PKEHL PQEST PQUKI PRINS 7X8 7S9 L.6 PUEGO |
| ID | FETCH-LOGICAL-c409t-490a5ac9d14d32e9b438c83c9aaa5c6f638f06613a8afd446db0f6c97fd8017a3 |
| IEDL.DBID | M48 |
| ISSN | 1660-3397 |
| IngestDate | Wed Aug 27 01:30:55 EDT 2025 Sun Aug 24 03:52:49 EDT 2025 Fri Jul 11 04:55:46 EDT 2025 Fri Jul 25 10:33:07 EDT 2025 Mon Jul 21 05:51:30 EDT 2025 Tue Jul 01 03:19:59 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Spiromastix sp brominated depsidone fungus antibacterial effects |
| Language | English |
| License | https://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c409t-490a5ac9d14d32e9b438c83c9aaa5c6f638f06613a8afd446db0f6c97fd8017a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-4874-2922 0000-0002-4978-4083 0000-0001-9469-8857 0000-0003-4738-0517 0000-0002-7524-8049 |
| OpenAccessLink | https://www.proquest.com/docview/2930978538?pq-origsite=%requestingapplication% |
| PMID | 38393049 |
| PQID | 2930978538 |
| PQPubID | 2032365 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_619463815c744a3eb2bde063c131b7b3 proquest_miscellaneous_3040459016 proquest_miscellaneous_2932023575 proquest_journals_2930978538 pubmed_primary_38393049 crossref_primary_10_3390_md22020078 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-Feb-03 |
| PublicationDateYYYYMMDD | 2024-02-03 |
| PublicationDate_xml | – month: 02 year: 2024 text: 2024-Feb-03 day: 03 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Marine drugs |
| PublicationTitleAlternate | Mar Drugs |
| PublicationYear | 2024 |
| Publisher | MDPI AG |
| Publisher_xml | – name: MDPI AG |
| References | Liu (ref_17) 2023; 62 Niu (ref_14) 2016; 108 Nelson (ref_21) 2021; 72 Harris (ref_2) 1985; 107 Wang (ref_8) 2022; 40 Xu (ref_3) 2014; 54 Jeschke (ref_4) 2010; 66 Prudhomme (ref_6) 2000; 7 Chen (ref_18) 2022; 144 ref_20 Molchanova (ref_9) 2020; 10 Niu (ref_12) 2021; 11 Agarwal (ref_1) 2017; 117 Bister (ref_10) 2003; 4 Yang (ref_16) 2023; 13 Niu (ref_11) 2014; 77 Fraley (ref_7) 2018; 28 Rai (ref_5) 2000; 343 Guo (ref_15) 2022; 20 Chen (ref_22) 2021; 7 Niu (ref_13) 2015; 13 Larsen (ref_19) 2022; 602 |
| References_xml | – volume: 28 start-page: 1992 year: 2018 ident: ref_7 article-title: Halogenase engineering and its utility in medicinal chemistry publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2018.04.066 – volume: 13 start-page: 2526 year: 2015 ident: ref_13 article-title: New polyphenols from a deep sea Spiromastix sp. fungus, and their antibacterial activities publication-title: Mar. Drugs doi: 10.3390/md13042526 – volume: 20 start-page: 627 year: 2022 ident: ref_15 article-title: New antibacterial depsidones from an ant-derived fungus Spiromastix sp. MY-1 publication-title: Chin. J. Nat. Med. – volume: 77 start-page: 1021 year: 2014 ident: ref_11 article-title: Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus publication-title: J. Nat. Prod. doi: 10.1021/np5000457 – volume: 72 start-page: S17 year: 2021 ident: ref_21 article-title: National estimates of healthcare costs associated with multidrug-resistant bacterial infections among hospitalized patients in the United States publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciaa1581 – volume: 54 start-page: 69 year: 2014 ident: ref_3 article-title: Halogen bond: Its role beyond drug-target binding affinity for drug discovery and development publication-title: J. Chem. Inf. Model. doi: 10.1021/ci400539q – volume: 108 start-page: 229 year: 2016 ident: ref_14 article-title: Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2015.09.037 – volume: 144 start-page: 19225 year: 2022 ident: ref_18 article-title: Depside bond formation by the starter-unit acyltransferase domain of a fungal polyketide synthase publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.2c08585 – volume: 117 start-page: 5619 year: 2017 ident: ref_1 article-title: Enzymatic halogenation and dehalogenation reactions: Pervasive and mechanistically diverse publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.6b00571 – volume: 66 start-page: 10 year: 2010 ident: ref_4 article-title: The unique role of halogen substituents in the design of modern agrochemicals publication-title: Pest Manag. Sci. doi: 10.1002/ps.1829 – volume: 7 start-page: 884 year: 2021 ident: ref_22 article-title: A marine antibiotic kills multidrug-resistant bacteria without detectable high-level resistance publication-title: ACS Infect. Dis. doi: 10.1021/acsinfecdis.0c00913 – volume: 343 start-page: 1750 year: 2000 ident: ref_5 article-title: Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia publication-title: N. Engl. J. Med. doi: 10.1056/NEJM200012143432402 – volume: 10 start-page: 14805 year: 2020 ident: ref_9 article-title: Halogenation as a tool to tune antimicrobial activity of peptoids publication-title: Sci. Rep. doi: 10.1038/s41598-020-71771-8 – volume: 40 start-page: 1729 year: 2022 ident: ref_8 article-title: Chemistry, biosynthesis, and biological activity of halogenated compounds produced by marine microorganisms publication-title: Chin. J. Chem. doi: 10.1002/cjoc.202200064 – volume: 4 start-page: 658 year: 2003 ident: ref_10 article-title: Bromobalhimycin and chlorobromobalhimycins—Illuminating the potential of halogenases in glycopeptide antibiotic biosyntheses publication-title: ChemBioChem doi: 10.1002/cbic.200300619 – volume: 62 start-page: e202214379 year: 2023 ident: ref_17 article-title: Didepside formation by the nonreducing polyketide synthase Preu6 of preussia isomera requires interaction of starter acyl transferase and thioesterase domains publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202214379 – volume: 602 start-page: 135 year: 2022 ident: ref_19 article-title: Emergence of methicillin resistance predates the clinical use of antibiotics publication-title: Nature doi: 10.1038/s41586-021-04265-w – volume: 7 start-page: 1189 year: 2000 ident: ref_6 article-title: Recent developments of rebeccamycin analogues as topoisomerase I inhibitors and antitumor agents publication-title: Curr. Med. Chem. doi: 10.2174/0929867003374138 – volume: 13 start-page: 3919 year: 2023 ident: ref_16 article-title: Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2023.05.036 – volume: 11 start-page: 29661 year: 2021 ident: ref_12 article-title: Chlorinated metabolites with antibacterial activities from a deep-sea-derived Spiromastix fungus publication-title: RSC Adv. doi: 10.1039/D1RA05736G – ident: ref_20 – volume: 107 start-page: 6652 year: 1985 ident: ref_2 article-title: The role of the chlorine substituents in the antibiotic vancomycin: Preparation and characterization of mono- and didechlorovancomycin publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00309a038 |
| SSID | ssj0035894 |
| Score | 2.3819304 |
| Snippet | Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus... Eleven new brominated depsidones, namely spiromastixones U-Z5 ( - ) along with five known analogues ( - ), were isolated from a deep-sea-derived fungus sp.... Eleven new brominated depsidones, namely spiromastixones U-Z5 (1-11) along with five known analogues (12-16), were isolated from a deep-sea-derived fungus... |
| SourceID | doaj proquest pubmed crossref |
| SourceType | Open Website Aggregation Database Index Database |
| StartPage | 78 |
| SubjectTerms | Antibacterial activity Antibacterial agents antibacterial effects Antibiotic resistance Antibiotics Antiinfectives and antibacterials Antimicrobial agents Bacteria brominated depsidone Bromination Carbon Deep sea Deep sea environments Deep water Drug resistance Enterococcus faecium Fermentation Fungi fungus Gram-positive bacteria Metabolites Methicillin methicillin-resistant Staphylococcus aureus Minimum inhibitory concentration Natural products NMR Nuclear magnetic resonance Sodium Sodium bromide Sodium bromides spectral analysis Spiromastix sp Staphylococcus infections Vancomycin |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT8QgECbGkxfj2_oKRuNJYrtAgaO6bjYejImaeLIBCsle1sZ2jf57B9iHHowXry1N6cwwM1-Z-UDoVIBVMFpawi0ThPnSEOkFJ85JoTXEe2Ej2-ddOXxit8_8-dtRX6EmLNEDJ8FdBJQNNlJwKxjTFICgqR3EVVvQwggTeT4h5s3AVPLBlEvFEhkpBVAP4L4HID-Ewx_hJ7L0_55axhAzWEOr09wQX6Y5raMlN95AZ_eJXPrzHD8ueqXac3yG7xe005-b6AUQdahrgRQS910DVhZo-HH40Yovx93IJF5meEFiLG5xaC3BGga7hjw4Tfpw-x2eHoADmLT4oRm9heqhbvSB22YLPQ1uHq-HZHp6ArGA2TrCVK65tqouWE17ThlGpZXUKq01t6UHoXrINwqqpfY1oMLa5L60SvgaopbQdBstj2GiuwjndSGkVtbnuWOmNFpQz4tw0pippZIyQyczoVZNIsmoAFwE0VcL0WfoKsh7PiIQW8cLoO5qqu7qL3Vn6GCmrWq62toKUpbQjgK-O0PH89uwTsLmhx6710kc04vcPvz3MRQ8GgvNuGWGdpIlzGcLSF6FLcm9__iKfbQCk2Gx-pseoOXubeIOIbnpzFG04y-FUfaY priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest - Health & Medical Complete保健、医学与药学数据库 dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagXLggWl6hBRmBeqpFsrZj-1QV2lXFAVVqK-2JyE-0l910k0X033fGye6KQ7nGjjyy5_XZ48-EfFGgFYLXnkkvFBOpdkwnJVmMWlkL8V75zPb5s768FT9mcjZuuHVjWeXGJ2ZHHZYe98i_QljCKwdgn6ftHcNXo_B0dXxC4yl5htRlqNVqtgVcXGojBkpSDtAeIP4EoD4GxX-CUObqfzzBzIFm-pK8GDNEejYs6T55EhcH5PhqoJi-P6E3uxtT3Qk9plc78un7V-QX4GqsboFEkp7HFnQNyfgpbrfSs0U_dwM7Mwww8BZ3FC-YUAudY8uuo2Xn0PwH_p6CG1h39Lqdr7CGqJ__pV37mtxOL26-X7LxDQXmAbn1TJjSSutNqETgk2ic4Npr7o21Vvo6gfklyDoqbrVNAbBhcGWqvVEpQOxSlr8hewsQ9B2hZaiUtsansozC1c4qnmSF7425oI3WBfm8mdSmHagyGoAYOPXNbuoL8g3ne9sD6a3zh-XqdzNaS4NbKyBZJb0SwnJA_y5ESKZ8xSunHC_I0Wa1mtHmumanIQX5tG0Ga8EjELuIy3XuM8kMP_LxPhz8msAruXVB3g6asJUW8LzBg8n3_xfgkDyHYUSu7uZHZK9freMHSF569zFr6ANxAu74 priority: 102 providerName: ProQuest |
| Title | Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38393049 https://www.proquest.com/docview/2930978538 https://www.proquest.com/docview/2932023575 https://www.proquest.com/docview/3040459016 https://doaj.org/article/619463815c744a3eb2bde063c131b7b3 |
| Volume | 22 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEB7yuPRSmj7dpItKS05RsVeSJR9KyWsJhYalycKeaiRZCgtl4669IfvvM5L3QUMDvRlLQmI00swnab4B-CxRKzjLLRWWS8p9bqjyUlDnlNQa7b20ke3zMr8Y8e9jMd6CVf7OpQCbf0K7kE9qNPv95f7P4hsu-K8BcSJkR-jeRwgfjN027KJFkiGTwQ--vk1gQsWEiFme456DBrijKX3U9i_DFPn7n3Y6o_EZvIDnS6-RHHfTvAdbbvoSDocd7fTiiFxvoqiaI3JIhhtC6sUr-IVYO7x4QeeSnLka9S8Q9JNwBEuOp-3EdIzN2EHHZdyQEHRCNFZ2Nb1ymp5h8R22HuDWMG_IVT2ZhXdF7eSeNPVrGA3Or08v6DKvArWI5lrKi1QLbYsq4xXru8JwpqxittBaC5t7XJIePZGMaaV9hXixMqnPbSF9hfZMavYGdqY40HdA0iqTShfWp6njJjdaMi-ykIPMVKpQKoFPK6GWdUefUSLsCKIvN6JP4CTIe10jUF7HH7ezm3K5gspw3IIjy4SVnGvmTN9UDh0sm7HMSMMSOFjNVrlSoxKdmRCogrt6Ah_XxbiCwrWInrrbeazTj6w_4uk6DPc6HsJ08wTedpqwHi1i_CJcVr7_jx724Rl-8fjsmx3ATjubuw_o1bSmB9tyLHuwe3J-OfzZi2cDvajGD2Kn9_k |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VcoAL4k1KASOgp1pNYid2DggVltWWlqpSt9KeSG3HQXtgN91kgf1T_EZmkn2IQ7n1GjuJNZ63Pd8AvFXIFVKkjidOKi7L1HJdqoR7r5UxaO-Va9E-T9PBhfwySkZb8GdVC0PXKlc6sVXUxdRRjvwAzRKVHKB8fqiuOHWNotPVVQuNji2O_eIXhmz1-6Me7u-7OO5_Hn4a8GVXAe4wlmm4zEKTGJcVkSxE7DMrhXZauMwYk7i0RIYs0Q5HwmhTFhgtFTYsU5epskBtrozA796C22h4Qwr21Ggd4IlEZ7KDQBUiCw9-FHEcUi5Q_2P02t4A1zu0rWHr34d7S4-UHXYs9AC2_OQh7J11kNaLfTbcVGjV-2yPnW3ArheP4BvG8XSbBh1X1vMV8jaB_zNK77LDSTO2HRo0_qDDSa4ZFbQwg5N9xc-94T0c_olv91HtzGt2Xo1ndGepGf9mdfUYLm6Euk9ge4ILfQYsLCKlTebKMPTSptYoUSYR9Tezhc60DuDNiqh51UFz5BjSEOnzDekD-Ej0Xs8gOO32wXT2PV9KZ06pHFxZlDglpRHexrbw6Ly5SERWWRHA7mq38qWM1_mGIwN4vR5G6aQjFzPx03k7J24RhZLr5wjUo5JKgNMAnnacsF6tQP-VDkJ3_r-AV3BnMPx6kp8cnR4_h7v4S9neLBe7sN3M5v4FOk6NfdlyK4PLmxaPv_yALHQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb9MwFH8anYS4IL7JGGAE7DSrSezEzgGhja7aGKoqtkk7kdmOjXqgzZoW6L_GX8dzPlpxGLddYyexnt-n_d7vAbwTyBWcpYYmhgvKXaqpdCKh1kqhFNp7YWq0z1F6fME_XyaXW_Cnq4XxaZWdTqwVdTEz_oy8j2bJlxygfPZdmxYxHgw_ltfUd5DyN61dO42GRU7t6heGb9WHkwHu9fs4Hh6dfzqmbYcBajCuWVCehSpRJisiXrDYZpozaSQzmVIqMalD5nRokyOmpHIFRk6FDl1qMuEK1OxCMfzuHdgWPirqwfbh0Wj8tbMDLJEZbwBRGcvC_o8ijkN_Mij_MYF1p4Cb3dvazA0fwP3WPyUHDUM9hC07fQR74wbgerVPzjf1WtU-2SPjDfT16jF8w6je59agG0sGtkRO960AiD_sJQfTxUQ32ND4gwY1uSK-vIUonGxLemYVHeDwT3x7iEpoWZGzcjL3GUyLyW9SlU_g4lbo-xR6U1zocyBhEQmpMuPC0HKdaiWYSyLf7UwXMpMygLcdUfOyAerIMcDxpM83pA_g0NN7PcODa9cPZvPveSuruT_YwZVFiRGcK2Z1rAuLrpyJWKSFZgHsdruVtxJf5Rv-DODNehhl1V_AqKmdLes5cY0vlNw8h6FW5b4gOA3gWcMJ69Uy9Gb9tejO_xfwGu6iaORfTkanL-Ae_pHXaeZsF3qL-dK-RC9qoV-17Erg6rYl5C_qbzIP |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Brominated+Depsidones+with+Antibacterial+Effects+from+a+Deep-Sea-Derived+Fungus+Spiromastix+sp&rft.jtitle=Marine+drugs&rft.au=Huang%2C+Zequan&rft.au=Liu%2C+Dong&rft.au=Chen%2C+Shang&rft.au=Ren%2C+Jinwei&rft.date=2024-02-03&rft.issn=1660-3397&rft.eissn=1660-3397&rft.volume=22&rft.issue=2&rft_id=info:doi/10.3390%2Fmd22020078&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1660-3397&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1660-3397&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1660-3397&client=summon |