Isolation, identification, and cytotoxicity of a new isobenzofuran derivative from marine Streptomyces sp. W007

A new isobenzofuran derivative （1） was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and...

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Bibliographic Details
Published inChinese journal of oceanology and limnology Vol. 34; no. 2; pp. 386 - 390
Main Author 张宏宇 谢则平 娄婷婷 姜鹏
Format Journal Article
LanguageEnglish
Published Heidelberg Science Press 01.03.2016
Springer Nature B.V
Subjects
Absolute configuration
Bacteria
BGC-823
breast neoplasms
Cancer
Chemical compounds
Cytotoxicity
Earth and Environmental Science
Earth Sciences
electrospray ionization mass spectrometry
ESI-MS
Gastric cancer
humans
Lung cancer
lung neoplasms
Marine
Marine biology
NMR
Nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
Oceanography
S4 Coastal Biotechnology
stomach neoplasms
Streptomyces
Toxicity
Two dimensional analysis
分离测定
海洋链霉菌
生物毒性
细胞毒性
苯并呋喃
鉴定
marine streptomycete
isobenzofuran derivative
absolute configuration
cytotoxicity
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ISSN0254-4059
2096-5508
1993-5005
2523-3521
DOI10.1007/s00343-015-4326-0

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Summary:A new isobenzofuran derivative （1） was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1H-1HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.
Bibliography:A new isobenzofuran derivative （1） was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1H-1HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.
marine streptomycete; isobenzofuran derivative; absolute configuration; cytotoxicity
37-1150/P
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0254-4059
2096-5508
1993-5005
2523-3521
DOI:10.1007/s00343-015-4326-0