Complete Androgen Insensitivity Syndrome—A Review

Abstract This review paper highlights important diagnostic and therapeutic concerns for girls with Complete Androgen Insensitivity Syndrome (CAIS). CAIS is an androgen receptor defect disorder associated with vaginal and uterine agenesis in women with a 46,XY karyotype. The major clinical issues sur...

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Published inJournal of pediatric & adolescent gynecology Vol. 21; no. 6; pp. 305 - 310
Main Authors Oakes, Meghan B., MD, Eyvazzadeh, Aimee D., MD, Quint, Elisabeth, MD, Smith, Yolanda R., MD, MS
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2008
Subjects
Androgen-Insensitivity Syndrome - diagnosis
Androgen-Insensitivity Syndrome - therapy
Female
Genetic disorder
Hormone therapy
Humans
Male
Obstetrics and Gynecology
Pediatrics
Testicular feminization
Vaginal agenesis
Vaginal dilatation
Genetic disorder
Vaginal dilatation
Vaginal agenesis
Testicular feminization
Hormone therapy
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Summary:Abstract This review paper highlights important diagnostic and therapeutic concerns for girls with Complete Androgen Insensitivity Syndrome (CAIS). CAIS is an androgen receptor defect disorder associated with vaginal and uterine agenesis in women with a 46,XY karyotype. The major clinical issues surrounding this syndrome include timing of gonadectomy, hormone replacement, vaginal dilation, and attention to psychological issues.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2007.09.006